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www.chemicalsknowledgehub.com


www.chemicalsknowledgehub.com


The firm describes this as “the first and only machine in the world that combines 100% visual inspection and sorting with counting and bottle filling”.


CPhI Festival of Pharma: What’s new in equipment?


The ongoing CPhI Festival of Pharma has seen a number of new product announcements in the fields of equipment to address emerging needs. Some are on show at the dedicated New Product Gallery, while others have been released externally.


N


oble has launched AdhereIT, which is described as “the first fully interchangeable, connected add-on solution that can work across a multitude of autoinjector platforms”. It was developed in partnership with Aptar Pharma, which has invested heavily in digital healthcare across all routes of drug administration over the past three years.


AdhereIT functions by pairing a patient’s autoinjector via Bluetooth technology to their mobile phone, to which existing Aptar applications can be downloaded. The related onboarding platform allows home care professionals to monitor patients’ progress via a smart analytical dashboard.


The device is available in two design options for one- or two-handed injections. It detects an injection event and provides real-time visual, audio and haptic feedback about whether this was performed correctly. The aim of all this is to improve patient adherence to self-injection regimes while also making them less traumatic. A giant in the medical technology field, BD, likewise presented some advances in pre-fillable parenteral drug delivery systems in the New Product Gallery. Both innovations are designed for self-administration as well as use in clinical settings. The BD Evolve On-body Injector is designed for programmable continuous, episodic or delayed delivery of up to 3 mL doses of biologic drugs. “It is meant to be programmable, with connected capabilities, and to enable subcutaneous administration … with up to three days of wear,” the company says.


The company also launched the Neopak XtraFlow, a pre-fillable glass- based syringe solution featuring an 8 mm needle with thinner-wall cannula technology thus addressing the trend towards shorter needles for lower injection forces to reduce pressure drop and enhance flow. In the same field, medical technology company ApiJect introduced


the ApiJect Prefilled Injector. This is a two-part parenteral system comprising a pre-filled blow-fill-seal container and a needle hub with a pre-attached connector, so that the user can inject the drug by squeezing the container. It is designed for 0.1-2.0 mL doses. From West Pharmaceutical Services come the new Daikyo D Sigma


AdhereIT


elastomeric components for injectable medicines. These are designed to reduce particulate and variability, while mitigating patient safety risks, the company says. Key attributes include: • Vision inspection at 0.01 mm², tighter AQL and ISO 8871-3 particulate counting to minimise drug safety risk and enhance patient protection • Full dimension measurement, to reduce the risk of variability • Clean D21-7H Grey rubber formulation for low levels of extractables and volatiles


• Ready-to-use or ready-to-sterilise quality • Daikyo Flurotec lamination, improving compatibility and minimising interaction between closure and drug


• RB2 silicone coating technology, for subvisible particle reduction and enhanced machinability Sensum, a specialist in automatic visual inspection systems for the pharmaceuticals and related industries, showcased the Spine Fibo, an advance on the Spine, which has been on the market for ten years.


The Spine Fibo visually inspect all surfaces of each product, removes defective products and immediately fills bottles with good product only. By bringing together two processes, it is claimed, both costs and risks in pharmaceutical production are reduced. Ackley, which makes precision machinery to print, laser mark and laser drill bulk tablets, capsules and softgels of all shapes and sizes, has two innovations on show at the New Product Gallery at CPhI. The VIP Laser Drill + NIR is said to be the first ever tablet drilling machine to incorporate near-infrared spectroscopy with precision CO2 laser drilling and vision inspection for osmotic controlled-release products. It has an output of up to 60,000 products/hour and offers “ease of use and fast, accurate analysis of solid dosage forms”, the company claims. Ackley also announced that its Cantilever Ramp Laser is now available with precision, non-contact UV laser technology for identification, counterfeit protection and brand recognition purposes. This system uses a continuous motion, multi-lane carrier bar system that exposes the top surface of the product for laser processing and vision inspection and marks indelible logos on to up to 150,000 tablets or capsules/hour. Secoya has added controlled crystallisation technology to its range of equipment for the continuous production of pharma ingredients, alongside crystallisation, pervaporation, encapsulation and particle generation, and intensified chemical synthesis. It is claimed to open new possibilities for the crystallisation of small molecules. By using small diameter capillaries, the new technology can master supersaturation conditions. Reaction parameters can be set so that the nucleation rate is adjusted to obtain the desired final crystal size, from 3 to 400 µm, in a single step. Target morphism and a narrow crystal size distribution can also be achieved. No physical micronisation is required so low crystal-size powder exhibits an excellent flowability and thus excellent powder handling capacities, Secoya adds.


Ackley


Aslo to address the issue of patient non-compliance, Röchling Medical, which offers customized components and assemblies, notably plastic primary packaging solutions and drug delivery devices, is launching the Connect-e-Cap.


This has electronics and sensor technology integrated into it, to combine with NFC connectivity and support patients in taking their medicine correctly, by giving immediate feedback on the correct use of their medicine. There is also a wide range of features allows for identifying complex patterns of patient behaviour and multi-cause non-adherence.


ApiJect Prefilled Injector 6 Autumn 2020


Connect-e-Cap Autumn 2020 7


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