Microscopy & Microtechniques 81 New Platform to Replicate Large Scale Freeze Drying Systems Launched
Linkam Scientific Instruments announces the launch of the FDVS platform, a lyophilisation system to replicate large scale freeze drying processes. Replicating large scale industrial freeze drying processes as smaller test runs is an effective way to save time, cut costs and perfect the technicalities of an operation run. With this in mind, Linkam engineers have created the new Freeze Drying Vial System - FDVS.
Building on the experience gained from the FDCS Freeze Drying stage, Linkam launch the FDVS, a chamber system with the capability to house up to seven lyophilisation vials. By incorporating vials, the FDVS works with greater sample volume and uses enough material to better simulate large scale industrial processes while minimising sample wastage.
While it saves time and money, the unit has been designed to save space. It is supplied on an ergonomically-designed table housing the controller units with the stage, optical microscope and imaging system mounted on top. By keeping the system compact, it conserves vital benchtop space.
The system was built with the scientific process in mind and as such comes with several specialised components which are essential to the freeze drying process. The optical system can be controlled in the X, Y and Z axes with a 10x darkfield lens mounted in line with the freeze drying stage. With this specially designed optical set-up, monitoring and tracking the position of the sublimation interface can be done simply and efficiently. Real time imaging allows the user to see structural changes in their samples as lyophilisation occurs in the vials. A built-in cold trap removes any excess moisture.
The system is fitted with two vacuum sensors, a capacitive and a Pirani-type sensor, which allow accurate measurement throughout the drying process and detection of the end point of primary drying. The top of the stage also features a vial stopper which allows the open vials to be closed once the freeze drying process is complete.
With the FDVS system, the new Optical DSC and TASC Image Processing module, Linkam now provides a range of Thermal Analysis tools to meet the needs of developing freeze drying protocols within the pharmaceutical industry.
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New Camera Delivers Intelligent Imaging with Innovative Features
Helping to save time and increase comfort at the microscope, Olympus’ new DP74 camera for brightfield and fluorescence delivers intelligent imaging with a range of innovative features designed to facilitate the workflow and enhance return on investment (ROI).
Able to produce a faster and more fluid live image than ever before, the DP74 camera now features a 60 fps live image. While lower frame rates can slow down everyday operations like panning and focusing, the DP74’s 60 fps delivers an experience that is remarkably similar to looking through the oculars. This not only enables enhanced comfort at the microscope by reducing reliance on the oculars, but also facilitates on-screen discussion and collaboration, for both small and big audiences.
Olympus’ DP74 camera is specially designed to image at a high sensitivity in both brightfield and fluorescence applications. This combination makes the DP74 ideally suited for a wide range of life science applications, particularly where samples with different types of staining are used on the same microscope. The DP74 also significantly improves the workflow of many industrial applications, where challenging samples with a highly variable brightness can be clearly visualised in the live image thanks to the LiveHDR function.
Saving time and pushing the boundaries of any microscope, the DP74 also features a new ‘Position Navigator’ function. This feature, which enables the camera to understand and remember structures on the sample, allows the creation of a sample map in real-time by simply moving the manual stage. No expensive encoded or motorised stages are required, making the DP74 a cost-effective alternative for upgrading any microscope.
When working on low-emitting fluorescent samples, the DP74 camera automatically recognises the challenging illumination situation and applies an active noise reduction function. This results in a fast live image while searching for the field of interest, even when long exposure times are required, and in a clean snapshot as soon as the image is stationary again.
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Quartz Microscope Slides and Coverslips
UQG Optics Ltd have been manufacturing and supplying quartz microscope slides and coverslips for 60 years. Using high quality quartz, the microscope slides and coverslips are supplied to laboratories worldwide. UQG Optics provides a large size and thickness range and can also supply these products in alternative materials, including UV fused silica for low fluorescence and sapphire. Additionally, AR and ITO coatings can also be applied. Other laboratory glasses available include substrates made in borosilicate optical glasses and custom sized glass cover slips. Thickness include #No0 0.10mm, thick 0.075/0.125, #No1 0.15mm thick 0.13/0.17mm thick, #No1.5 0.17mm thick 0.16/.019mm thick, #No2 0.20mm thick 0.18/0.25mm thick and substrates 0.50mm and 1.00mm thick.
As a direct OEM supplier to many scientific instrument manufacturers, customers’ are buying direct from the source at very competitive prices. Large stocks are held at the Cambridge, UK factory, ready for immediate shipment. Please see the full range at
www.uqgoptics.com.
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Live Cell Imaging System Provides Convenience and Consistency for Live Cell Analysis
BioTek’s BioSpa Live Cell Imaging System fully automates live cell imaging workflows for robust, real-time results without the need for manual intervention. The BioSpa System has a compact footprint for use on benchtops and in biosafety cabinets, and consists of the BioSpa™ 8 Automated Incubator and Cytation™ 5 Cell Imaging Multi-Mode Reader. BioTek’s liquid handling instruments may also be linked with the BioSpa System for complete, walk away automation from sample preparation through image analysis.
In the System, BioSpa 8 provides precise, real-time environmental control and monitoring for live cell assays in up to 8 lidded or unlidded plates or other labware. It incorporates a robotic gripper to move sample plates or vessels from BioSpa 8’s incubator drawer to Cytation 5 for automated image capture, processing and quantitative analysis of live cell assays. Imaging capabilities include fluorescence, brightfield, colour brightfield and phase contrast, up to 60x, along with advanced imaging and analysis features such as single or multi-colour imaging, montage creation, time-lapse, Z-stacking and Z-projection, digital phase contrast, image stitching and video creation.
BioSpa’s software seamlessly integrates with Gen5™ Microplate Reader and Imager Software for increased workflow efficiency during short and long-term cell-based assays.
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