10 Analyse CO and CO2 at ppb Levels Easily and Accurately High Quality Solvents for Analytical and Preparative Separations Available


Honeywell Research Chemicals provides a wide range of high quality solvents under the Riedel-de Haën™ portfolio including more than 250 Chromasolv™ high-purity solvents. Chromasolv product lines deliver superior purity, stability, and lot-to-lot consistency, making them ideal for a variety of analytical and preparative separations utilising UHPLC, LC-MS, HPLC, GC and spectrophometric analysis. Chromasolv products have been custom designed to meet the requirements of each of the specifi c analytical methods, and are suitable for use in a diverse array of industries. Product specifi cations are achieved through careful material selection and processing along with stringent internal quality control systems. Honeywell’s approach to high purity products, reliability and environmental considerations is refl ected by our ISO 9001 and RC 14001®


certifi cations. Consistently meeting the requirements demanded by these global standards for quality management and environmental management demonstrates an uncompromising commitment to excellence in both areas. Chromasolv LC-MS solvents are designed specifi cally with low content of alkaline impurities such as calcium, magnesium, potassium, and sodium, which can interfere in the analysis by forming artifacts with the analyte. Chromasolv Plus, our multipurpose version, is tested for suitability in HPLC with gradient analysis, spectrophotometry, environmental testing, and some LC-MS applications. Chromasolv Gradient solvents provide added testing for suitability in HPLC with gradient analysis and spectrophotometry, and eliminate any impurity peaks which could be caused by the solvent rather than by the compound being tested - solvent impurity peaks are less than 0.005 absorbent units. Chromasolv for HPLC instrumentation and organic synthesis applications are glass distilled, submicron fi ltered and undergo rigorous specifi cation testing to provide you with lot-to-lot consistency.


40812pr@reply-direct.com New Chiral Column Offered


Low-level detection of carbon monoxide (CO) and carbon dioxide (CO2


Restek’s methanizer (CH4izer) for Agilent GCs


allows ppb-level determination of CO and CO2 using a cost-effective FID instead of more expensive instrumentation. The methanizer is factory set to 380°C to ensure effi cient and complete conversion of CO and CO2


to CH4 , but the operator can easily


adjust the temperature as desired with the touch of a button. This unit controls temperatures precisely and reliably to within ± 1°C of the defi ned set point and the actual temperature is shown in real time on an easy-to-read display. The Restek®


methanizer is less


cumbersome than other models and is designed for easy installation and fast catalyst tube replacement so you spend more time analysing samples and less time on maintenance.


41312pr@reply-direct.com ) is critical for many applications.


Millipore Sigma, through its collaboration with ES Industries, offers a number of innovative and unique selective chiral stationary phases designed to solve chiral applications. Chirality has become critically important in the pharmaceutical, chemical and agricultural industries. Due to subtle differences, compounds that exhibit chiral activity can produce dramatically different pharmacological effects in biological systems. As a result, the demand for stereo selective separation techniques and analytical assays to evaluate the enantiomeric purity of chiral compounds has increased. Chiral chromatography in the forms of HPLC and SFC has become a necessary tool; not only for the analytical determination of enantiomeric purity, but also for the isolation and purifi cation of enantiomers. As a leader in chiral separations, the ChromegaChiral products offer a broad range of Chiral Stationary Phases (CSP’s) for analytical and preparative chromatography needs. Existing CSP’s can separate a wide variety of chiral mixtures; however there are still enantiomeric mixtures that are diffi cult to separate limiting their characterisation. This provides the drive to develop new CSP’s with differing chiral selectivities, e.g. ChromegaChiral CCA-F4 a chiral phase with embedded Fluorine atoms. The addition of a fl uorine atom into a phenyl carbamate amylose structure can be useful in promoting fl uorophilic retention mechanism which can provide improved retention for fl uorinated compounds. A fl uorophilic retention mechanism can be particularly useful in medicinal chemistry and drug discovery, where more than a third of newly approved small molecule drugs contain fl uorine. ChromegaChiral CCA-F4 can be used in SFC or HPLC. Product features Include: excellent selectivity range; high pressure limit; wide range of applications; fast optimisation; superior resolution and effi ciency; one column for bBoth SFC and HPLC use; easy scale-up from analytical to preparative columns.


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Self-Regenerating Purifi er for Chromatography Gases


Asynt has introduced GasTrap gas purifi ers for analytical laboratories using Gas Chromatography (GC), High Performance Liquid Chromatography (HPLC) or Mass Spectrometry (GC/MS) instrumentation.


Gas purity is essential in any GC, HPLC or GC/MS application requiring high sensitivity. Available in optimised models for


Helium, Hydrogen, Nitrogen and pure air, GasTrap gas purifi ers dramatically reduce the levels of contaminants, enhance the purity of lower grade helium, and help ensure instrument stability, reproducibility as well as lowering running costs.


Laboratory gases for GC, HPLC and GC/MS are typically supplied in pressurised cylinders that contain trace impurities. Even with speciality high purity gas supplies trace contaminants of up to 20ppm Oxygen, water, Carbon Dioxide, Neon and Argon are present which increase proportionately as the cylinder pressure drops. Unlike disposable gas fi lters that are time consuming, costly and cannot remove gases such as Neon, Argon or Nitrogen, based upon patented Pressure Swing Adsorption (PSA) technology, GasTrap gas purifi ers remove all of contaminant trace gases and self-clean every cycle.


Operated via intuitive touchscreen software, GasTrap gas purifi ers can save you up to £2000.00 per Gas Chromatograph thereby effectively paying for itself within six months. In addition, disposal of fi lters is dramatically reduced and using a GasTrap gas purifi er, labs can save money through using lower grade gases. GasTrap gas purifi ers have been designed to operate automatically for 10 years with no servicing or consumables required.


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Challenges During mAb Purifi cation


For purifi cation of monoclonal antibodies, high demands are required from the separating material. Factors infl uencing the binding characteristics of IgG are pH, linear velocity and/or salt concentration (conductivity) at the time the sample is loaded onto the column. Therefore, a material with highly stable performance is required with regard to all those factors. In order to demonstrate the performance of YMC-BioPro materials, several studies have been performed. High binding capacities are achieved regardless of elution of pH. Therefore, milder eluting conditions for Adalimumab can be selected. BioPro SmartSep maintains higher binding capacity values over a wider range of linear velocity. This will increase product throughput for the purifi cation work without loss of ef fi ciency.


BioPro SmartSep has higher salt concentration tolerance. This simplifi es the desalting pro cess after Protein A chromatography and will help to shorten the production process. BioPro SmartSep materials meet the highest demands for the purifi cation of monoclonal antibodies. High binding capacity is achieved regardless of elution of pH, linear velocity or salt concentration. This allows purifi cation processes to be carried out more effi ciently.


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INTERNATIONAL LABMATE - JANUARY/FEBRUARY 2017


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