Imogene Grimes
(KePRO), was recently promoted to vice trimester. More recently, he published
president of informatics and reporting. several papers examining a possible asso-
Imogene Grimes was recently appointed
Harris will report to Chris Bouvier, ciation between a class of popular medica-
vice president of Data Sciences Strategic
KePRO’s chief information officer, who tions and cardiovascular risk.
Services for PAREXEL International
said, “Meghan has been with KePRO for Makuch is a Fellow of the American
Corporation. Grimes, a leading
many years and has provided tremendous Statistical Association and a member of
biostatistician, is contributing to the con-
support and knowledge for both tactical Phi Beta Kappa, the oldest undergraduate
tinued expansion of PAREXEL’s data sci-
and strategic objectives, product and ser- honors organization in the United States.
ence services, including data manage-
vice delivery and support, and new busi- Makuch earned his BA in mathematics from
ment, biostatistics, and applications of
ness development.” the University of Connecticut in 1972.
information technology to the clinical
Harris will provide strategic leader-
development process.
ship for further development of KePRO’s Daniel McCaffrey
“The biopharmaceutical industry
health informatics and reporting service
is undertaking more complex clinical
The RAND Corporation recently
lines, creating and delivering a full con-
research, such as using adaptive designs
appointed Daniel McCaffrey as the PNC
tinuum of quality services to both internal
with the potential to detect safety and effi-
chair in policy analysis. The position,
and external customers. She will contin-
cacy signals earlier,” said Mark A. Goldberg,
supported by a $500,000 gift from the
ue to perform her duties from KePRO’s
president of clinical research services
PNC Foundation, was created to enable
Cleveland office.
and perceptive informatics at PAREXEL
an exceptional researcher to devote a por-
Harris earned her BS in mathemat-
International. “Grimes will bring experi-
tion of his or her time to supporting new
ics from Malone College in Canton,
ence with advanced statistical methods to
research on emerging or underappreciated
Ohio, and her MS in statistics from the
PAREXEL, which we believe will be a tre-
issues, mentoring promising researchers,
University of Akron. She also earned a
mendous asset to our clients in bringing
and providing leadership within RAND’s
project management certification from
novel treatments to patients sooner.”
Pittsburgh office.
Villanova University. Harris is an expert
Prior to joining PAREXEL, Grimes
McCaffrey leads the RAND Statistics
in SAS, SPSS, Minitab, MapInfo, SQL,
served as vice president of statistics,
Group, which provides statistical analy-
and the Microsoft suite of products. She
data management, and informatics at
sis to the wide variety of research projects
is a member of the SAS User Group,
Regeneron Pharmaceuticals, where she
conducted at RAND. After beginning his
the Cleveland Chapter of the American
provided statistical and data management
tenure in Santa Monica, McCaffrey joined
Statistical Association, the American
expertise for all phases of drug develop-
the Pittsburgh office in 2002.
Society for Quality, and the American
ment research. Previously, she was vice
McCaffrey, a 2007 recipient of a RAND
Health Quality Association.
president of statistics and data manage-
President’s Award and a Fellow of the
ment at Yamanouchi Pharma America,
Robert W. Makuch
American Statistical Association, is recog-
now Astellas Pharma, and held senior
nized as one of the nation’s top experts in sta-
management positions at Pfizer and
Robert W. Makuch, professor in tistical analysis, as well as an authority on the
GlaxoSmithKline.
the Division of Biostatistics at Yale models that underpin pay-for-performance
Grimes holds a PhD in biostatistics
School of Public Health, received the systems across public organizations.
from The University of North Carolina
Distinguished Alumni Award from the “Dan has contributed a wealth of
at Chapel Hill and master’s and bachelor’s
University of Connecticut at a reception expertise to a variety of RAND projects,
degrees from The University of North
and banquet April 17. including research on education, child wel-
Carolina at Greensboro. A focus of Grimes’
During the ceremony, Makuch dis- fare, health, and drug and alcohol abuse,”
career has been regulatory submissions of
cussed his time at the university as an said Barry Balmat, director of RAND’s
marketing applications using electronic
undergraduate student and his subsequent Pittsburgh office. “Dan is the ideal choice
media and, in particular, ensuring an
life’s work. His primary research interests to continue RAND’s commitment to excel-
understanding of regulatory expectations
involve methodologic issues in the design, lence in the statistical analysis that underlies
for statistics and data management. She
conduct, and analysis of clinical studies. much of our work.”
currently serves as a board member of the
An area of particular interest is the appro- “Early childhood education is an issue
Data Quality Research Institute and is a
priate design and analysis of active control of major focus for our company’s com-
member of several industry organizations,
equivalence studies, where he described munity involvement efforts,” said James
including the International Biometric
in a series of papers how control groups E. Rohr, chair and chief executive officer
Society. Grimes has presented several train-
should be selected, how the sample size of PNC. “Dan’s skills have been applied to
ing courses and authored numerous articles
for these studies is determined, and what many areas, including program evaluation
about data management and statistics.
constitutes appropriate methods of analy- and pay for performance—both important
sis. In the mid-1980s, this research led issues in early childhood and K–12 edu-
Meghan Harris
Makuch and his collaborators to design cation. PNC’s support will enable him to
AZT treatment studies for preventing continue making breakthroughs on relevant
Meghan Harris, who works at the
HIV transmission from pregnant mothers concerns that affect children of all ages.”
national medical management firm
to their unborn children during the third
Keystone Peer Review Organization Inc.
34 AMSTAT NEWS JUNE 2008
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