AL | Science News TITLE continued
Immersion Microscopy Metalenses for Biological Imaging Overcome Challenges of Lens-Polishing Methods
Because of their distinctive shape, most front lenses of high-end microscopes are hand-polished. This expensive and time-consuming process produces lenses that only work within a few specific refractive indices of immersion liquids. If one specimen is in blood and another is immersed in water, two different lenses would need to be created.
Researchers from the John A. Paulson School of Engineering and Applied Sciences at Harvard designed a front planar lens that can be tailored for any immersion liquid, as well as for multiple layers of different refractive indices. This is especially important for imaging biological material such as skin. “Our immersion metalens can take into account the refractive indices of epidermis and dermis to focus light on the tissue under human skin without any additional design or fabrication complexity,” said graduate student Alexander Zhu.
According to Federico Capasso, the Robert L. Wallace Professor of Applied Physics and Vinton Hayes Senior Research Fellow in Electrical Engineering, “Tis new lens has the potential to overcome the drawbacks and challenges of lens-polishing techniques that have been used for centuries.”
Study Charts Course of Tau Deposits in Alzheimer’s Patients
A research team led by Professor Agneta Nordberg at the Karolinska Institutet used PET brain imaging to measure the spread of tau deposits as well as the amyloid plaque associated with Alzheimer’s disease. Te researchers studied the energy metabolism of the brain cells and examined changes throughout the course of the disease.
“Tere are no previous reports on how tau deposits spread aſter 17 months into the disease. Our results can improve understanding of tau accumulation in Alzheimer’s disease, help ongoing research to quantify the effect of tau vaccines, and enable early diagnosis,” said Professor Nordberg. “We also saw a strong direct correlation between size of deposit and episodic memory impairment,” she added. “Tis could explain why the disease progresses at such a varying rate from one patient to the other. Tat said, tau doesn’t seem to have much of an effect on the global general memory, which is more reasonably related to brain metabolism.”
Fluorescent Detection of Flu Virus Leads to Quicker Diagnosis, Treatment
University of Notre Dame researchers developed a new method to detect neuraminidase, which is located on the surface of the influenza virus. The new approach makes the virus visible to the naked eye and
AMERICAN LABORATORY 7 JUNE/JULY 2017
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