24 chromatography • spectroscopy
orthogonal techniques.” Te 1260 Infinity Hybrid SFC/ UHPLC system delivers LC-like sensitivity over the UHPLC power range. It is the only SFC system providing 600bar capability. Te hybrid system is economical because customers purchase only one instrument to perform both types of separations. It also conserves valuable bench space. In SFC mode, the instrument uses standard- grade gaseous carbon dioxide for considerable cost savings over SFC-grade carbon dioxide. Tis is in addition to the reduced solvent consumption and waste generation of SFC compared to LC.
Meanwhile, designed as the gas chromatographers’ GC-MS system, Bruker’s new SCION TQ GC-MS/ MS promotes ease of use and increased workflow in busy analytical laboratories. Te advantages offered by hardware innovations - reducing the instrument footprint by half but at the same time improving performance over traditional gas chromatography systems – are supplemented by the utility and ease of use of the novel SCION compound based scanning (CBS) software.
Bruker’s software for the SCION TQ includes a number of important tools and features to make method set up, data analysis and comparisons of similar spectra much easier. With gas chromatographers in mind, the SCION software package includes: a CBS multiple reaction
complete with the Bruker compound library, which details 2500 MRM transitions. Results are presented in a standard pro-forma accepted across the industry and may be cross referenced against known spectral libraries to aid interpretation and final delivery.
Pittcon newcomers Pittcon once again played host to a number of exciting new releases. Waters, for example, says that it ushered in a new category of separation science with the introduction of the Waters ACQUITY UPC2 System which expands the boundaries of reversed phase liquid chromatography (LC) and of gas chromatography (GC) separations and offers a replacement option for normal phase chromatography applications (Fig. 2).
Fig. 2. The Waters ACQUITY UPC2 System expands the boundaries of reversed phase liquid chromatography and of gas chromatography separations.
monitoring (MRM) compound library for easy set up of methods; additional spectral libraries such as NIST, Wiley, Pfleger/Maure/ Weber (PMW); plug in to multiple user-customisable spectral libraries with automatic search functions; and Bruker’s mass spectrometry (MS) workstation software.
Jim Koers, Bruker CAM software
High speed, high precision sample analysis
T
o speed up R&D in areas such as pharmacokinetics, it has become increasingly necessary to analyse large numbers of samples
at high speed and high precision. In response to these demands, the new Nexera MP ultra high performance liquid chromatograph utilising the SIL-30ACMP
www.scientistlive.com
manager, said: “To put this into context, manual TQ method development for a 200 compound method would require around 12,000 keystrokes and take several days. With CBS, we can achieve a fully optimised method in a matter of hours, and with less than 200 keystrokes.”
Te SCION TQ system comes
multiplate autosampler has been developed by Shimadzu. The SIL-30ACMP achieves an ultrafast injection
performance exceeding that of current models while maintaining ultra low carryover performance. In addition, up to six microtiter plates can be loaded, enabling a maximum of 2304 samples to be analysed continuously. By incorporating these various functions, the Nexera MP is ideally suited as a front-end LC for LC/MS and LC/MS/MS systems. Even on conventional models, Shimadzu says that use of the SIL-30ACMP speeds up high-throughput analysis. The new device has also been designed with an
Employing the principle of ultraperformance convergence chromatography (UPC2), Waters ACQUITY UPC2 System is a novel analytical system that gives laboratories an indispensable tool for tackling tough-to-analyse compounds including hydrophobic and chiral compounds, lipids, thermally-labile samples and polymers.
“ACQUITY UPC2 took on every challenge we threw at it. At one point, we ran a very challenging 18-compound mixture, including amines, vitamin isomers, steroids, and antibacterial agents – all in
emphasis on open access. Here, the ability to load different plates on each rack becomes all the more advantageous. The SIL-30ACMP provides a flexible analysis environment where, for example, one person can be performing on-time analysis with 1.5 mL vials while another is loading a microtiter plate for large-volume analysis. Vials or plates can be replaced even while analysis is in progress. Moreover, the SIL- 30ACMP is designed to prevent hands from coming into contact with the arm or other moving parts (closed-type design) while achieving open access. This prevents unexpected accidents during sample replacement from happening.
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52