ARTICLE | nutrition | niacinamide can be used by aged cutaneous cells
to restore intracellular nicotinamide, possibly by coenzyme homeostasis2
. Effects of diet on skin A range of studies have been published during the
past 10 years addressing the relationship between diet and the health of the skin. in 2001, a European study involving 24 women with diagnosed anorexia nervosa was conducted to determine whether cutaneous differences exist between restrictive and bulimic-type disorders. in all patients, the most frequent skin manifestations were3
:
■ Dry skin (58.3%) ■ Hair effluvium (50%) ■ nail changes (45.8%) ■ Cheilitis (41.6%) ■ Acne (41.6%) ■ Generalised pruritus (16.6%) ■ Hyperpigmentation (12.5%) ■ Poor wound healing (least frequent skin manifestation). An epidemiological study from 20054
found evidence
suggesting a positive relationship between fat intake and basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). there was an inconsistent association for retinol, a vitamin A derivative, β-carotene, and BCC or SCC development4
. it is possible that — depending
on the nature of the disease — in the case of some cancers, dietary factors may have more impact either in the early or later stages of the disease4
. other studies
have shown that supplementation with β-carotene can provide protection against skin damage from sunlight after a minimum of 10 weeks’ supplementation in the diet. Protection increased with each month of continued supplementation5
.
Effects of UV stress on skin the fatty acid composition of the epidermis is approximately 25% unsaturated6
and relatively
chemically unstable with regard to oxidative stress. Photodamage, inflammation and the appearance of ageing are typical responses to ultraviolet exposure and other forms of oxidative stress. Furthermore, studies of immunosuppressed transplant recipients and patients with biopsy-confirmed skin cancer have proven that ultraviolet
(uV) light radiation-induced
immunosuppression is a risk factor for the development of skin cancer in humans7
. the uVB spectrum inhibits Photodamage,
inflammation and the appearance of ageing are
typical responses to ultraviolet exposure and other forms of oxidative stress.
48 ❚ September 2011 |
prime-journal.com
antigen presentation, which induces the release of immunosuppressive cytokines, and elicits DnA damage that is a molecular trigger of uV-mediated immunosuppression. Dietary botanicals are of interest because they have been shown to inhibit uV-induced immunosuppression and photocarcinogenesis7
. it is hypothesised that underuV–stress, skin antioxidants
undergo depletion and must be replaced in order to delay deterioration of the skin and the appearance of ageing. there is limited information correlating the role of daily food intake with actinic skin damage.
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