NEWS
Genomics software platform aids research at Riken Omics Science Center
Riken Omics Science Center (OSC), a Japanese research centre focusing on developing genome-wide technologies, has implemented CLC Bio’s high- throughput sequence analysis infrastructure to manage and analyse large quantities of genomics data. The software
platform will empower both OSC’s scientists and OSC’s Genome Network Analysis Service (GeNAS).
Riken OSC facility director, Dr Carsten Daub, commented: ‘It is customary for us to develop our own in-house software that is tailor-made to our very
specialised needs. However, we were very impressed with the performance and flexibility of CLC Bio’s software for a wide range of high-throughput sequence analysis projects and decided that it would be faster and more efficient for us to adopt their enterprise platform.’
Space technology company extends CAE capability
OHB Technology, a space technology company, has increased its usage of Altair Engineering’s HyperWorks to consolidate its pre- and post- processing tools. It will operate one software suite across all subsidiary companies of the group, including OHB-System, MT
Aerospace, Luxspace and Kayser- Threde.
In this context, HyperWorks was selected to be the standard computer-aided engineering (CAE) development platform across the entire OHB Technology organisation.
HyperMesh and HyperView will
be used in all current and future development projects, among them the Galileo satellites, a project OHB recently won, as well as other satellite and space projects, including the SGEO and the EnMAP satellites or to develop racks for the International Space Station.
Simulation cuts engine calibration test time
AVL List, a company building powertrain systems (combustion engines, hybrid systems, electric drives), has developed a combustion controller that reduces test bed time for engine calibration by approximately 50 per cent, compared to implementation using manual programming. The real-time combustion controller was developed using MathWorks Model-Based Design tools.
Engine calibration involves controlling an engine to its optimum combustion position, which has traditionally been a slow process of trial and error with an engine running on the test bed. To address this challenge, AVL developed a
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combustion controller that drastically reduces test bed time for engine calibration teams. AVL built a system-level model in Simulink to verify the controller in simulation over its full range of operation and test the reaction to limit violations to protect the engine under test.
Real-Time Workshop and the
AVL ARTE.Lab tool helped the team quickly generate code from the controller model and execute it on the test bed. In addition to reducing development time, AVL integrated a new test bed with the controller in two days and cut testing time by 80 per cent on a recent pilot project. ‘Using MathWorks tools was
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critical to the success of our combustion controller, which will, in turn, enable our test bed customers to reduce testing time,’ said Dr Klaus Rothbart, product manager at AVL. ‘Integrating MathWorks tools gives us an advantage because a majority of our customers also use Matlab and Simulink, and can customise the combustion controller without additional ramp-up time.’
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US FDA finds
solution to manage pharmacogenomic data
The US Food and Drug Administration (FDA) is using the Genomics Reviewer Desktop (GRD) from Strand Life Sciences to enable its reviewers to manage and analyse pharmacogenomic data submitted through its Voluntary Exploratory Data Submissions (VXDS) programme. GRD will enable FDA to integrate analyses needed to reconstruct a sponsor’s interpretation of exploratory biomarker data by using multiple genomics tools and methods. This effort contributes to the development of recommendations for the submission of genomic data. GRD will be integrated with
FDA’s ArrayTrack and with other third-party analysis software tools. GRD is built on Avadis, Strand’s workflow-driven data analysis and visualisation platform that powers software products such as GeneSpring and Sarchitect. As part of this agreement, FDA has also licensed Strand’s Avadis software.
‘There are a number of analysis tools, methods, and databases available to the FDA, along with our own ArrayTrack, to analyse data submissions submitted as part of the VXDS programme,’ said Dr Federico Goodsaid, associate director for operations in genomics, Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US FDA. ‘GRD will help FDA reviewers to develop integrated data interpretation that is based on using multiple analysis tools and databases, as well as capture the underlying analysis process. A solution such as GRD will be advantageous to both the FDA and the industry to manage pharmacogenomic data submissions.’
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