search.noResults

search.searching

note.createNoteMessage

search.noResults

search.searching

orderForm.title

orderForm.productCode
orderForm.description
orderForm.quantity
orderForm.itemPrice
orderForm.price
orderForm.totalPrice
orderForm.deliveryDetails.billingAddress
orderForm.deliveryDetails.deliveryAddress
orderForm.noItems
Contents


DDW the quarterly business review of drug discovery & development


Publisher and Editor-in-Chief Robert Jordan Robert@rjcoms.com


Digital & Circulation Manager Giles Jordan


Consultant Editor Dr Roger Brimblecombe


Contributing Author Dr John Comley


Design & Production Melissa Chadderton rhubarbcreative@sky.com


Editorial Advisors Dr Steve Arlington Dr Nigel Brown


Dr Rathnam Chagaturu Dr David Clough Dr Richard Eglen Dr Gregory Lennon Dr Keith Mansford Dr Stephen Naylor Dr George Poste Dr Amber Salzman Dr David U’Prichard Dr Timothy Wells Dr Rene Ziegler


Drug Discovery World (ISSN 14694344) is published quarterly by RJ Communications & Media Ltd, 39 Vineyard Path, London SW14 8ET, United Kingdom. Tel: +44 (0)20 8487 5656 Fax: +44 (0)20 8487 5666 E-mail: Robert@rjcoms.com


Subscription Rates Annual Subscription (four Issues): £89 UK & Europe; $165 USA & Canada; £99 Rest of World


Airfreight and mailing in the USA by agent named Air Business Ltd, c/o Worldnet Shipping Inc, 156-15, 146th Avenue, 2nd Floor, Jamaica, NY 11434, USA. Periodicals postage paid at Jamaica NY 11431. US Postmaster: Send address changes to DRUG DISCOVERY WORLD DDW, Air Business Ltd, c/o Worldnet Shipping Inc, 156-15, 146th Avenue, 2nd Floor, Jamaica, NY 11434, USA Subscription records are maintained at RJ Communications & Media Ltd, 39 Vineyard Path, London, SW14 8ET, United Kingdom


Air Business Ltd is acting as our mailing agent.


© 2017 RJ Communications & Media Ltd All rights reserved.


No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means electronic, mechanical, photocopying, recording or otherwise without the prior written permission of the copyright holder. While the publishers believe that all information contained in this publication was correct at the time of going to press, they can accept no liability for any inaccuracies that may appear or loss suffered directly or indirectly by any reader as a result of any advertisement, editorial, photographs or other material published in Drug Discovery World.


dr ug discov e r y wo r l d contents


VOLUME 18 ISSUE 4 ● FALL 2017 Introduction


Dr Roger Brimblecombe Consultant Editor


Drug Discovery


Drug Discovery in the Age of Big Data Dr Prem Premsrirut


Drug Delivery


Nanomedicines – Exploring the Past, Present and Future Professor Yvonne Perrie and Dr Euan Ramsay


Screening


Phenotypic Screening – Advancing the Science From Discovery to Regulatory Science Dr Ellen L. Berg


Epigenetics


Epigenetics – Unlocking the Potential for Personalised Medicine Dr Jason Mellad


Drug Discovery


How One Mouse Strain is Revolutionising Drug Discovery Dr Philip E. Dubé


Screening Novel Drug Targets From Phenotypic Screening Dr Jim Freeth, Dr Elizabeth Kingsley and Jo Soden


Informatics Blockchain Technology in Drug Discovery: Use-Cases in R&D Dr Richard Shute


Therapeutics


Oral Peptide Therapeutics – A Holy Grail or Quixotic Quest? Dr Paul Shields


Lab Automation


Collaborative Robots Are Redefining Lab Automation Peter Harris


7 8


17 26


33 39 45 52


65 59


Front cover illustration courtesy of Alfred Pasieka/Science Photo Library Drug Discovery World Fall 2017 5


Page 1  |  Page 2  |  Page 3  |  Page 4  |  Page 5  |  Page 6  |  Page 7  |  Page 8  |  Page 9  |  Page 10  |  Page 11  |  Page 12  |  Page 13  |  Page 14  |  Page 15  |  Page 16  |  Page 17  |  Page 18  |  Page 19  |  Page 20  |  Page 21  |  Page 22  |  Page 23  |  Page 24  |  Page 25  |  Page 26  |  Page 27  |  Page 28  |  Page 29  |  Page 30  |  Page 31  |  Page 32  |  Page 33  |  Page 34  |  Page 35  |  Page 36  |  Page 37  |  Page 38  |  Page 39  |  Page 40  |  Page 41  |  Page 42  |  Page 43  |  Page 44  |  Page 45  |  Page 46  |  Page 47  |  Page 48  |  Page 49  |  Page 50  |  Page 51  |  Page 52  |  Page 53  |  Page 54  |  Page 55  |  Page 56  |  Page 57  |  Page 58  |  Page 59  |  Page 60  |  Page 61  |  Page 62  |  Page 63  |  Page 64  |  Page 65  |  Page 66  |  Page 67  |  Page 68  |  Page 69  |  Page 70  |  Page 71  |  Page 72