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Contents


DDW the quarterly business review of drug discovery & development


Publisher and Editor-in-Chief Robert Jordan Robert@rjcoms.com


Head of Digital Giles Jordan


Consultant Editor Dr Roger Brimblecombe


Design & Production Melissa Chadderton rhubarbcreative@sky.com


US Advertising Manager Jonathan Sismey Jonathan@rwwcompany.com


Editorial Advisors Dr Steve Arlington Dr Nigel Brown Dr Rathnam Chagaturu Dr David Clough Dr Richard Eglen Dr Gregory Lennon Dr Keith Mansford Dr Stephen Naylor Dr George Poste Dr Amber Salzman Dr David U’Prichard Dr Timothy Wells Dr Rene Ziegler


Drug Discovery World (ISSN 14694344) is published quarterly by RJ Communications & Media Ltd, 39 Vineyard Path, London SW14 8EL, United Kingdom. Tel: +44 (0)20 8487 5656 Fax: +44 (0)20 8487 5666 E-mail: Robert@rjcoms.com


The US annual subscription price is USD140. Airfreight and mailing in the USA by agent named WN Shipping USA, 156-15, 146th Avenue, 2nd Floor, Jamaica, NY 11434, USA. Periodicals postage paid at Jamaica NY 11431. US Postmaster: Send address changes to DRUG DISCOVERY WORLD DDW, WN Shipping USA, 156- 15, 146th Avenue, 2nd Floor, Jamaica, NY 11434, USA. Subscription records are maintained at RJ Communications & Media Ltd, 39 Vineyard Path, London SW14 8EL, United Kingdom. Air Business Ltd is acting as our mailing agent.


© 2019 RJ Communications & Media Ltd All rights reserved.


No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means electronic, mechanical, photocopying, recording or otherwise without the prior written permission of the copyright holder. While the publishers believe that all information contained in this publication was correct at the time of going to press, they can accept no liability for any inaccuracies that may appear or loss suffered directly or indirectly by any reader as a result of any advertisement, editorial, photographs or other material published in Drug Discovery World.


d r u g d i s c o v e r y wo r l d contents VOLUME 20 ISSUE 2 ● SPRING 2019


Introduction Dr Roger Brimblecombe Consultant Editor


Business The Cure for Going it Alone: How M&A Will Drive Oncology Research in 2019 Dr Michael Seiler


Immunotherapy Knocking Out Cancer With a One-Two Punch Dr Mark Chao, Dr Ranjana H. Advani and Dr Jens Peter Volkmer


Genomics From Genotype to Phenotype: Leveraging Functional Genomics in Oncology Dr Ultan McDermott, Dr Steve Rees, Dr Susan Galbraith, Dr Mike Snowden and Dr Mene Pangalos


Flow Cytometry Flow Cytometry – The Advanced Systems Overcoming Drug Discovery Pain Points Helen Stewart-Miller and Dr Richard Massey


Cell Culture Three-Dimensional Organoid Cell Culture – Optimising Disease Models for Research and Drug Discovery Dr Amanda Linkous, Hilary Sherman, Iris Li and Dr Richard Eglen


Business Integrated Platform-Drug Discovery and Development Companies Part II: Comparative Analysis Dr Stephen Naylor and Dr Kirkwood A. Pritchard Jr


Natural Products A Modern Approach to Herbal Healing – Mining Plant Genomes Michelle Vierra


Business Fostering Multidisciplinary Collaboration in Drug Discovery Professor Zeynep Erden, Dr Shiko Ben Menahem, Professor Georg von Krogh, Dr Andreas Schneider, Dr Guido Koch and Dr Hans Widmer


7 9


16 23


31 39 46


58 52


Front cover illustration courtesy of SCIEPRO/Science Photo Library Drug Discovery World Spring 2019 5


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