Display Technology
Novel Optical LFD Reader: Pushing the limits of quantitative readout R
esearch by CDT (the European Research Centre of Sumitomo Chemical Group) has resulted in the development of a new technique that can improve the sensitivity of lateral flow devices (LFDs) by an order of magnitude, while speeding up testing and reducing errors. LFDs consist of an immunoassay incorporated into a transport medium such as a nitrocellulose strip. These assays have traditionally been regarded as a convenient, low cost threshold test based on the presence or absence of a developing colour line. Incorporation of an electronic device as a reader has broadened LFDs’ appeal by enabling easy collection of data, improving connectivity, removing many sources of human error, and potentially providing quantitative output. Further expansion of the appeal of LFDs is limited by some inherent flaws in the technology, particularly in detection limits, speed and defects/errors. CDT has developed a dynamic two- colour optical reader technology that can expand the usefulness of the LFD strip by improving the quality and accuracy of
reader technology. Using novel optics and data analysis algorithms, CDT has developed a solution that can be easily integrated into typical LFD optical readers. The approach corrects for local background and thus has the potential to improve
assay lower limit of detection, compensate for sample viscosity errors, eliminate tests containing errors faster and allow measurement of coloured samples. Such improvements can enable performance in a portable reader that would
normally be restricted to a desktop unit, opening up new diagnostic applications in human primary/distributed care, veterinary and agriculture environments.
cdtltd.co.uk
www.cieonline.co.uk
Components in Electronics
February 2020 15
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