search.noResults

search.searching

saml.title
dataCollection.invalidEmail
note.createNoteMessage

search.noResults

search.searching

orderForm.title

orderForm.productCode
orderForm.description
orderForm.quantity
orderForm.itemPrice
orderForm.price
orderForm.totalPrice
orderForm.deliveryDetails.billingAddress
orderForm.deliveryDetails.deliveryAddress
orderForm.noItems
Vision systems


Can new advanCeS in CMOS replaCe SCMOS SenSOrS in biOMediCal appliCatiOnS?


C


omplementary metal-oxide- semiconductor (CMOS) technology now offers the advanced imaging


capabilities required for many biomedical applications, but can it replace the more expensive sCMOS (scientific CMOS) sensors? CMOS and sCMOS sensors have set the benchmark for both performance and value in machine vision in several industries, and this article will explain the benefits and costs of each technology for highly demanding imaging applications in biomedical and life sciences.


What is the difference betWeen cMOs and scMOs sensOrs?


Typically, a sCMOS sensor is thought of as a “next-generation” CMOS sensor. sCMOS technology was introduced to bridge the gap between new CMOS sensors and traditional CCD (Charge Coupling Device) sensors during the early phases of CMOS development. Initially, biomedical applications could not use CMOS sensors due to compromises in dynamic range, read noise, frame rates and resolutions. When sCMOS cameras were introduced, they used very similar design principles and fabrication techniques as CMOS sensors, but incorporated several features that helped them overcome initial CMOS shortcomings. This made sCMOS sensors well suited for scientific applications where low light performance, wide dynamic range, and high fidelity were critical. However, in the years since sCMOS cameras


were introduced, conventional CMOS sensors have improved significantly in terms of their quantum efficiency and the ability to reduce their own internal noise, making CMOS cameras a viable option for many advanced biomedical


applications. Furthermore, most CMOS cameras are significantly less expensive than sCMOS cameras. This factor alone has motivated many engineers and researchers to consider evaluating the latest CMOS sensor when they need to choose a microscopy camera, histology camera, cytology/cytogenetics camera, or epifluorescence camera for their application.


dO i need a cMOs Or a scMOs sensOr?


Whether to choose a CMOS or sCMOS sensor depends on a range of factors. If you are debating between the two, you are likely using epifluorescence illumination, because white light is bright enough to not require a sCMOS sensor. The suitability of one over the other can sometimes be as simple as how much light is reaching the camera, or a combination of performance parameters that are unique to a specific application. Regardless of CMOS or sCMOS, you should choose a monochrome sensor over the color equivalent for the inherent quantum efficiency benefit provided by a monochrome sensor. An sCMOS sensor is characterized by backside


illumination and large pixels helping reduce overall noise (like CCD technology). In addition, sCMOS cameras typically include a Peltier cooling system to reduce thermally generated noise over long exposures. Cameras using sCMOS sensors also need a high bandwidth interface such as CameraLink or CoaXpress with a frame grabber board, making such vision systems more complex, and consequently more expensive. To counter this, CMOS manufacturers have


continued making significant improvements in quantum efficiency (the ability to collect incoming photons), reducing read noise


46


April 2021 Instrumentation Monthly


Page 1  |  Page 2  |  Page 3  |  Page 4  |  Page 5  |  Page 6  |  Page 7  |  Page 8  |  Page 9  |  Page 10  |  Page 11  |  Page 12  |  Page 13  |  Page 14  |  Page 15  |  Page 16  |  Page 17  |  Page 18  |  Page 19  |  Page 20  |  Page 21  |  Page 22  |  Page 23  |  Page 24  |  Page 25  |  Page 26  |  Page 27  |  Page 28  |  Page 29  |  Page 30  |  Page 31  |  Page 32  |  Page 33  |  Page 34  |  Page 35  |  Page 36  |  Page 37  |  Page 38  |  Page 39  |  Page 40  |  Page 41  |  Page 42  |  Page 43  |  Page 44  |  Page 45  |  Page 46  |  Page 47  |  Page 48  |  Page 49  |  Page 50  |  Page 51  |  Page 52  |  Page 53  |  Page 54  |  Page 55  |  Page 56  |  Page 57  |  Page 58  |  Page 59  |  Page 60  |  Page 61  |  Page 62  |  Page 63  |  Page 64  |  Page 65  |  Page 66  |  Page 67  |  Page 68  |  Page 69  |  Page 70  |  Page 71  |  Page 72  |  Page 73  |  Page 74