LABORATORY INNOVATION
environments for bacterial cultivation and offers important advantages for laboratory managers over conventional technologies, including the anaerobic chamber and the gas-generating sachet system.
“The Anoxomat has been extremely useful in the growth and care of anaerobic cultures in my laboratory,” comments Scott Connolly, Microbiology Supervisor at VA Boston Healthcare. He continues: “It allows for advanced patient care when it comes to cultures that grow a variety of microbiological organisms. At the push of a button, we are able to simulate anaerobic conditions ideal for their growth.”
The Anoxomat anaerobic jar system is able to quickly create optimal conditions for the growth of anaerobic, microaerophilic, and capnophilic organisms.
improved turnaround time (TAT) in our osmolality service with the biggest benefit in an improved resilience around the way testing is performed, thus ensuring maximum and efficient staff utilisation allowing them to be more productive and resourceful.”
Another NHS Trust where the OsmoPRO is highly valued is Nottingham University Hospitals (NUH), where Specialist Biomedical Scientist in Clinical Chemistry, Hayden Powell has this to say: “Across our sites at Queens Medical Centre and Nottingham City Hospital, we receive approximately 450 serum and 320 urine osmolality requests on a monthly basis. Previously when analysing samples, we utilised two different osmolality instruments between the sites, and both required a manual transcription step prior to release.
“So, when the opportunity came available to replace our current osmometers, I gladly volunteered to take part in the validation and verification (V&V) of the new OsmoPRO from Advanced Instruments. To do this, I was tasked with calibrating the instrument ready for use, collecting trueness and precision data for the V&V, and creating a plethora of new documentation. Since its introduction,
I and many others within the laboratory would agree that the OsmoPRO has many benefits and improved workflow with the department greatly. The OsmoPRO has ensured a consistent and continued osmolality service for our users, as well as improved our daily workflow and minimised the risk of errors.”
Streamlining microbiology workflows
In 2007, Advanced Instruments began offering anaerobic systems. Responding to an increasing demand for process optimisation in clinical laboratories, Advanced Instruments acquired Mart Microbiology in 2007, marking the entrance onto the microbiology bench with the anaerobic jar system, Anoxomat. Patient outcomes rely on accurate isolation and identification of microorganisms promptly from microbiology laboratories. This is why hospital and research laboratories value Anoxomat’s ability to quickly create optimal conditions for the growth of anaerobic, microaerophilic, and capnophilic organisms. The latest version of this system, Anoxomat III, helps laboratories automatically and easily create exact and repeatable
The OsmoPRO has ensured a consistent and continued osmolality service for our users, as well as improved our daily workflow and minimised the risk of errors
Hayden Powell, Specialist Biomedical Scientist in Clinical Chemistry, Nottingham University Hospitals
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Standardising CSF cell counts In 2016, Advanced Instruments received 510(k) clearance from the US Food and Drug Administration (FDA) to market its GloCyte Automated Cell Counter System and GloCyte Low and High Level Controls. Cerebrospinal fluid (CSF) cell counts have traditionally been performed by haemocytometer chamber counts. As with other manual microscopic techniques, this method is subject to high interobserver variability and poor reproducibility. Body fluid (BF) cell counts are now widely performed on various haematology analysers in automated laboratories. However, positive bias at very low cell counts has limited implementation of automated CSF cell counting to the same extent as for other body fluid cell counts. Advanced Instruments recognised the difficult nature of accurate CSF cell counting as a key priority for haematology laboratories and took on the GloCyte as a key priority in its clinical product portfolio. The GloCyte uses fluorescence
microscopy and two reagents to enumerate total nucleated cells (TNCs) and red blood cells (RBCs) in under five minutes. A nucleic dye specifically stains the nucleus of TNCs and an antibody stain tags antigens on the surface of RBCs making it easy for staff of all skills levels to obtain accurate results. Stained samples are deposited onto test cartridges and vacuum is applied to capture cells on a membrane. An image of the membrane is captured by a digital CCD camera and processed via a sophisticated algorithm eliminating errors associated with manual counting.
The accuracy of CSF cell counts is critical in clinical practice. Bristol Royal Infirmary has implemented the GloCyte Automated Cell Counter for CSF because it is the only reliable automated CSF cell counter solution available for budget- constrained hospitals, so explains Alexander Macphie, Senior Biomedical
OCTOBER 2024
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