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PPi Editor Andy Myall andymyall@stepcomms.com


Science Editor Brian Nation CSci FIBMS briannation@stepcomms.com


Publisher Geoff King geoffking@stepcomms.com


Business Manager Peter Moon


petermoon@stepcomms.com


Journal Administration Katy Cockle katycockle@stepcomms.com


Design Laurence Hallam


Publishing Director Trevor Moon trevormoon@stepcomms.com


Advisory Panel Dr Nigel Brown FIBMS Gavin Knight CSci FIBMS Wendy Leversuch CSci FIBMS Dr Suzy Lishman CBE FRCPath Dr Stephen MacDonald FRCPath Prof Gerry McKenna DSc CSci FIBMS Malcolm Needs CSci FIBMS Dr Sarah Pitt CSci FIBMS Dr John Rees FIBMS


Pathology in Practice may not be reproduced in any way without prior written consent of the publisher.


Step House, North Farm Road Tunbridge Wells Kent TN2 3DR Tel: 01892 779999


Email: info@pathologyinpractice.com ISSN 1465-9131


Register your details to receive free copies of the magazine. SCAN HERE


Creating a Community of Practice, see page 21


Securing the future of digital pathology NEWS ARTICLES


Management of risk: an action plan for pulling everything together


Building a resilient future: establishing a Community of Practice


Detection to direction: the future of precision oncology diagnostics


Hyperviscosity syndrome: a complication hiding in plain sight?


Precision oncology diagnostics, see page 27


Tackling sepsis and antimicrobial stewardship


GENie: specialist Genomic Online Individual Education from GenQA


POC PlGF testing: a paradigm shift in pre-eclampsia diagnosis


POCT Innovators event: The power to disrupt through diagnostics


Point-of-care PlGF testing, see page 50


Phaeochromocytoma and paraganglioma: testing for rare neuroendocrine tumours


Detection to direction: precision oncology diagnostics Oncology diagnostics are evolving from detecting cancer to guiding decisions


15 21 27 31 38 44 50 54 56 COVER STORY


across the entire patient journey. Screening is shifting from population-based tests to biomarker-led approaches such as Proclarix in prostate cancer, improving accuracy and reducing unnecessary investigations. Diagnostic precision is further enhanced by molecular tools like the Prostatype Genomic Classifier, which more accurately predicts prostate cancer outcomes than traditional methods and supports decisions such as active surveillance or focal therapy. Treatment selection is also being shaped by predictive biomarkers; for example, MAF gene testing in breast cancer helps identify patients more likely to benefit from adjuvant bisphosphonate therapy. As diagnostics advance, integration of laboratory systems, data, and clinical delivery has become essential. Source BioScience supports this shift by combining accredited cellular pathology with molecular and genomic testing capabilities, enabling end-to-end diagnostic pathways.


T: 0115 973 9012 E: enquiries@sourcebioscience.com W: www.sourcebioscience.com


WWW.PATHOLOGYINPRACTICE.COM DECEMBER 2025 3 5 7


CONTENTS


Volume 26 Issue 8 December 2025


www.pathologyinpractice.com OPINION


PATHOLOGY IN PRACTICE


PPi PIP cover Dec25.indd 1


www.pathologyinpractice.com VOLUME 26 • ISSUE 8 • DECEMBER 2025


MANAGEMENT OF RISK: PULLING TOGETHER AN ACTION PLAN


COMPLICATION HIDING IN PLAIN SIGHT? A RESILIENT FUTURE: ESTABLISHING


A COMMUNITY OF PRACTICE HYPERVISCOSITY SYNDROME:


DETECTION TO DIRECTION The future of precision oncology diagnostics


14/11/2025 10:56


PATHOLOGY IN PRACTICE


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