Cover story - advertising feature
Big innovations for the little ones
Löwenstein Medical provides an insight into the latest innovation developed to protect the lungs of the tiniest and most vulnerable patients.
Since Löwenstein Medical was founded in 1986, the company has been focused on the field of neonatology and has gained a reputation for pioneering advances in medical ventilation and thermal therapy systems for pre-term and neonates. The ventilation of pre-term and neonates is an
especially challenging discipline within intensive care medicine. The lungs of pre-term babies are not yet fully developed. The alveoli (air sacs) are smaller and fewer in number, resulting in
increased airway resistance and reduced lung compliance (lung elasticity). Immature lungs are extremely sensitive to
volutrauma (damage caused by excessive tidal volumes), barotrauma (damage caused by excessive airway pressures) and atelectrauma (damage caused by the repeated collapse and reinflation of the alveoli). This can lead to the development of a chronic lung disease, bronchopulmonary dysplasia (BPD), and to associated long-term damage. Pre-term babies also often have an irregular
respiratory pattern with central or mixed apnoea (pauses in breathing), which are caused by the immaturity of the central nervous system. This makes synchronous ventilation more difficult and requires ventilation modes that can respond to these irregularities. Over the past decades, Löwenstein Medical has set high standards in neonatal ventilation with the Leoni family, most notably the Leoni plus. Building on this expertise, the company set out to develop an innovative successor to the Leoni plus that integrates current scientific findings, technological advances, and practical requirements of neonatology. This resulted in the development of the LEONI 4 project – the
We ventilate pre-term babies with tiny lung volumes, weighing only 300 to 400 grams. For this, we need highly precise technology, as provided by Löwenstein. We can rely on these devices – they give us the confidence to provide optimal care for these extremely fragile children.
Dr. Ulrich Rochwalsky, Head of Neonatology, University Hospital Frankfurt.
www.clinicalservicesjournal.com Volume 25 I Issue 6 I June 2026
THE CLINICAL SERVICES JOURNAL
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company’s latest ventilator for pre-term and neonates, as well as children.
The LEONI 4 The new neonatal ventilator needed to be designed to the highest technical standards, with high medical sensitivity, while meeting stringent requirements for regulatory compliance. At the end of March 2025, the company received positive feedback from the certification body, allowing it to issue the EU Declaration of Conformity under the current Medical Device Regulation (MDR) – after less than five years of development. The LEONI 4 goes one step further towards the future – with an agile system that keeps operation intuitive, configuration needs-based and training requirements to a minimum. Paired with Instant View Technology, the system allows for immediate recognition of the current status and deviations at a glance, setting new standards in the reliable ventilation of premature babies.
Features and benefits With LEONI 4, all key functions are now even more advanced and secure – ensuring the technology is comfortably familiar, yet innovatively ahead of the curve. One of the key features includes the provision
of lung-protective high-frequency oscillation (HFO) ventilation, which enables spontaneous breathing without pressure peaks in invasive and non-invasive ventilation under HFO. LEONI 4 delivers the highest performance in high-frequency ventilation through the innovative double diaphragm principle. The optional volume guarantee provides
the child with a constant breathing volume. Spontaneous breathing and volume limitation
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www.clinicalservicesjournal.com I June 2026
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