PARTNER FEATURE ▶▶▶
Binding bacterial and fungal toxins
How will producers replace the benefits achieved with subtherapeutic antibiotic use in animal rations? That’s a question occupying many nutritionists and veterinarians that have made the switch to antibiotic-free production.
BY LEANN JOHNSTON, AMLAN INTERNATIONAL A
lthough it’s unlikely a single feed additive will ever completely replace the efficacy and performance benefits of antibiotics, there are solutions availa- ble that can address multiple poultry industry
challenges. One of the products on the market is Calibrin-Z from Amlan International, a natural, mineral-based feed addi- tive that binds both bacterial and fungal toxins. One of the biggest challenges for the poultry industry, particularly after the removal of in-feed antibiotics, is bac- terial enteritis caused by pathogens like Escherichia coli and more notably, Clostridium perfringens, the causative agent of necrotic enteritis. Add production losses associated with mycotoxin-contaminated feed, and you have two industry challenges that urgently need a natural control solution.
Binding bacterial toxins and mycotoxins Calibrin-Z isn’t your run-of-the-(feed)mill ingredient. It’s a highly efficacious, mineral-based feed additive that helps protect the intestinal health of poultry and livestock by ad- sorbing a broad spectrum of bacterial toxins and mycotoxins in the intestinal tract which are then eliminated harmlessly in the faeces. Unlike comparable products, it binds polar and nonpolar mycotoxins – that means aflatoxins, plus zearale- none, fumonisin, ochratoxin and T-2 toxin. It also binds the bacterial toxins that cause significant economic losses to pro- ducers, including C. perfringens-produced alpha-toxin and NetB toxin, as well as various exotoxins and endotoxin (LPS) from E. coli. The additive has these impressive binding capabilities due to its specific chemical and structural properties that – together with Amlan’s proprietary thermal processing method –
32 ▶ POULTRY WORLD | No. 1, 2022
promote the adsorption of a broad spectrum of microbial tox- ins. Thermal processing is a natural method that does not al- ter the chemical composition of Calibrin-Z and so avoids the harmful chemicals typically used by other companies to activate their mineral-based products. The mode of action for Calibrin-Z isn’t just about adsorbing microbial toxins; it can also quench the quorum-sensing mol- ecules that pathogenic bacteria use to communicate. Pre- venting cell-to-cell communication disrupts the expression of virulence genes that could lead to infection in the bird.
Performance benefits The production benefits of Calibrin-Z were demonstrated in a broiler mycotoxin challenge study that evaluated the abili- ty of various feed additives to reduce the toxic effects of concurrent aflatoxin and fumonisin exposure. The study was conducted at Instituto de Soluções Analíticas Microbiológi- cas e Tecnológicas (SAMITEC) in Santa Maria, Brazil. In the 21-day feeding trial, one-day-old male broiler chicks were randomly assigned to one of six dietary treatments that in- cluded four commercially available feed additives, sold as mycotoxin control products, added at an inclusion rate of 0.5%. A mycotoxin-challenged control diet was fed to all treat- ment groups except the unchallenged control (Table 1). The mycotoxins used in the challenge diet were aflatoxins B1, B2, G1 and G2 produced by Aspergillus parasiticus
PHOTO: AMLAN
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