pathogenic bacteria, enterotoxins and endotoxins to translo- cate into the bloodstream and enter other body parts. Lignans are able to directly modulate inflammation, as they can block signalling substances that promote the inflammation cascade. Furthermore, lignans show highly antioxidative effects due to radical scavenging, resulting in less stress for the gut mucosa and organs. All those characteristics help to control inflamma- tory reactions caused by infections. Thus, it might be hypothe- sised that using lignans could help reduce antibiotic use in animal production.
Practical little helpers In a novel approach to using bioactive substances derived from wood, the mode of action of the product Agromed ROI is based on wood lignans. The highly active phytonutrients (= lignans) support animals to combat inflammation, enabling them to perform to their maximum level. Containing highly active wood ingredients, this approach allows lowering of the energy demand for inflammatory processes. This energy sav- ing can be channelled into growth performance. The formulation of this lignan approach thus contributes to improved feed conversion ratio, supports the animal’s health status and consequently helps to optimise farm profitability. Animal trials have also shown that the inclusion of this lig- nan-based strategy in a diet gave performance results similar to and better than when antibiotics were included. However, the different stages of infection/inflammation need to be considered.
Inflammatory processes are usually present during an ani- mal’s lifespan. Mostly these occur at subclinical levels and cannot be seen. When they become visible or reach a clinical stage they need to be treated with pharmaceuticals. Wood lignans are a valuable tool in preventing inflammatory pro- cesses getting to a clinical stage. In a further development, wood lignans were combined with wood-derived phenolic acids, which in combination are highly potent in mitigating causes and consequences of diarrhoea by strengthening the gut barrier – promoting intact gut struc- ture and function. Agromed Protect has strong antioxidative effects that benefit gut mucosa and thus support the animal by preventing diarrhoea, reducing diarrhoea rate and severity and protecting gut integrity. Thus, it helps pigs cope in a chal- lenging period in their life, maintaining high performance and consequently contributes to a farm’s profitability.
Influencing swine physiology Selecting the proper raw material allows for phytonutrients rich in bioactive molecules which can benefit swine physiolo- gy and allow for best performance. With the use of wood lig- nans, animal nutrition company Agromed Austria was able to create a growth promoter preventing inflammation process- es. By combining the lignans with phenolic acids in a further step, a product was developed to act as a problem solver. Those solutions, used preventatively to minimise inflamma- tion, can be helpful tools to avoid the use of antibiotics in animal nutrition.
▶ PIG PROGRESS | Volume 38, No. 4, 2022 29
Lignans provide gut barrier sup- port, preventing pathogenic bacteria.
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