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CONTINUING EDUCATION :: CYTOMEGALOVIRUS INFECTION REFERENCES


1. Wang Y-Q, Zhao X-Y. Human Cytomegalovirus Primary Infection and Reactivation: Insights From Virion-Carried Molecules. Frontiers in Micro- biology. 2020;11.


2. Griffiths P, Reeves M. Pathogenesis of human cytomegalovirus in the immunocompromised host. Nature Reviews Microbiology. 2021;19(12):759-773.


3. CDC. About Cytomegalovirus (CMV). https://www.cdc.gov/cmv/overview. html. Published 2020. Accessed September 27, 2022.


4. Gupta M, Shorman M. Cytomegalovirus. In: StatPearls. Treasure Island (FL): StatPearls Publishing Copyright © 2022, StatPearls Publishing LLC.; 2022.


5. Mack I, Burckhardt MA, Heininger U, Prüfer F, Schulzke S, Wellmann S. Symptomatic Congenital Cytomegalovirus Infection in Children of Seroposi- tive Women. Front Pediatr. 2017;5:134.


6. CDC. Congenital CMV Infection. https://www.cdc.gov/cmv/clinical/ congenital-cmv.html. Accessed September 27, 2022.


7. Belzile JP, Sabalza M, Craig M, Clark AE, Morello CS, Spector DH. Tre- halose, an mTOR-Independent Inducer of Autophagy, Inhibits Human Cyto- megalovirus Infection in Multiple Cell Types. J Virol. 2016;90(3):1259-1277.


8. Goderis J, De Leenheer E, Smets K, Van Hoecke H, Keymeulen A, Dhooge I. Hearing loss and congenital CMV infection: a systematic review. Pedi- atrics. 2014;134(5):972-982.


9. Jakharia N, Howard D, Riedel DJ. CMV Infection in Hematopoietic Stem Cell Transplantation: Prevention and Treatment Strategies. Current Treatment Options in Infectious Diseases. 2021;13(3):123-140.


10. Clark AE, Sabalza M, Gordts P, Spector DH. Human Cytomegalovirus Replication Is Inhibited by the Autophagy-Inducing Compounds Trehalose and SMER28 through Distinctively Different Mechanisms. J Virol. 2018;92(6).


11. Griffiths P. The direct and indirect consequences of cytomegalovi- rus infection and potential benefits of vaccination. Antiviral Research. 2020;176:104732.


12. CDC. CMV: Clinical overview. https://www.cdc.gov/cmv/clinical/over- view.html. Accessed September 27, 2022.


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15. Prince HE, Lapé-Nixon MKP, New York 11754. Role of cytomegalovirus (CMV) IgG avidity testing in diagnosing primary CMV infection during pregnancy. Clin Vaccine Immunol. 2014;21(10):1377-1384.


16. Bonalumi S, Trapanese A, Santamaria A, D’Emidio L, Mobili L. Cyto- megalovirus infection in pregnancy: review of the literature. J Prenat Med. 2011;5(1):1-8.


17. CDC. Laboratory Testing. https://www.cdc.gov/cmv/clinical/lab-tests. html. Published 2020. Accessed September 2022, 2022.


18. Saldan A, Forner G, Mengoli C, Gussetti N, Palù G, Abate D. Testing for Cytomegalovirus in Pregnancy. J Clin Microbiol. 2017;55(3):693-702.


19. Adler SP. Screening for cytomegalovirus during pregnancy. Infect Dis Obstet Gynecol. 2011;2011:1-9.


20. Fitzpatrick D, Holmes NE, Hui L. A systematic review of maternal TORCH serology as a screen for suspected fetal infection. Prenat Diagn. 2022;42(1):87-96.


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22. Razonable RR, Inoue N, Pinninti SG, et al. Clinical Diagnostic Testing for Human Cytomegalovirus Infections. J Infect Dis. 2020;221(Suppl 1):S74-s85.


23. Maternal-Fetal Medicine Units Network. CMV calculator: Congenital Cytomegalovirus Infection after Maternal Primary Infection. https://mfmu- network.bsc.gwu.edu/web/mfmunetwork/cmv-calculator. Published 2022. Accessed September 27, 2022.


24. Rouse DJ, Fette LM, Hughes BL, et al. Noninvasive Prediction of Congenital Cytomegalovirus Infection After Maternal Primary Infection. Obstetrics & Gynecology. 2022;139(3):400-406.


25. Mikrobiologisch-infektiologischer-Qualitätsstandard, MiQ. MIQ issue: 12 DECEMBER 2022 MLO-ONLINE.COM


Ilana Heckler, PhD, is the Scientific Affairs Liaison at EUROIMMUN US. She holds a PhD in Chemical Biology for her studies on bacterial hemoprotein sensors of nitric oxide. As the Scientific Affairs Liaison, Dr. Heckler establishes scientific collaborations and assists in the validation of diagnostic assays for autoimmune and infectious diseases.


Maite Sabalza, PhD, is the Scientific Affairs Manager at EUROIMMUN US. Her academic background is in infectious diseases and diagnostics. In her role at EUROIMMUN US, she establishes relationships with key opinion leaders and supports the team with commercial activities including scientific collaborations, scientific marketing, and business development of diagnostics.


35b infection immunological methods part 2. https://shop.elsevier.de/miq- heft-35b-infektionsimmunologische-methoden-teil-2-9783437415326.html. Published 2016. Accessed October 10, 2022.


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27. Zelini P, Fornara C, Furione M, et al. Determination of anti-p52 IgM and anti-gB IgG by ELISA as a novel diagnostic tool for detection of early and late phase of primary human cytomegalovirus infections during pregnancy. J Clin Virol. 2019;120:38-43.


28. Schoppel K, Kropff B, Schmidt C, Vornhagen R, Mach M. The Humoral Immune Response against Human Cytomegalovirus Is Characterized by a Delayed Synthesis of Glycoprotein-Specific Antibodies. The Journal of Infectious Diseases. 1997;175(3):533-544.


29. Rothe M, Pepperl-Klindworth S, Lang D, et al. An antigen fragment encompassing the AD2 domains of glycoprotein B from two different strains is sufficient for differentiation of primary vs. recurrent human cytomega- lovirus infection by ELISA. J Med Virol. 2001;65(4):719-729.


30. Jummaat F, Ahmad S, Mohamed Ismail NA. 5-Year review on amnio- centesis and its maternal fetal complications. Horm Mol Biol Clin Investig. 2019;40(2).


31. CDC. Babies Born with Congenital Cytomegalovirus (CMV). https:// www.cdc.gov/cmv/congenital-infection.html. Published 2022. Accessed September 29, 2022.


32. Cannon MJ, Griffiths PD, Aston V, Rawlinson WD. Universal newborn screening for congenital CMV infection: what is the evidence of potential benefit? Rev Med Virol. 2014;24(5):291-307.


33. Ciobanu AM, Dumitru AE, Gica N, Botezatu R, Peltecu G, Panaitescu AM. Benefits and Risks of IgG Transplacental Transfer. Diagnostics (Basel). 2020;10(8).


34. Chiereghin A, Pavia C, Turello G, et al. Universal Newborn Screening for Congenital Cytomegalovirus Infection - From Infant to Maternal Infection: A Prospective Multicenter Study. Front Pediatr. 2022;10:909646.


35. PerkinElmer. Newborn screening solutions from sample to result. https:// rh.perkinelmer.com/newborn-products/#Kits. Accessed September 30, 2022.


36. PerkinElmer. DETECT cCMV IN A SINGLE DRIED BLOOD SPOT PUNCH. https://perkinelmer-appliedgenomics.com/home/products/neomdx-ccmv- real-time-pcr-assay/. Accessed September 30, 2022.


37. Minesotta Department of Health. Congenital cytomegalovirus approved for addition to newborn screening panel. https://www.health.state.mn.us/ news/pressrel/2022/newborn020222.html. Published 2022. Accessed Sep- tember 30, 2022.


38. Razonable RR, Humar A. Cytomegalovirus in solid organ transplant recipients-Guidelines of the American Society of Transplantation Infec- tious Diseases Community of Practice. Clin Transplant. 2019;33(9):e13512.


39. CDC. Guidelines for Preventing Opportunistic Infections Among Hema- topoietic Stem Cell Transplant Recipients. https://www.cdc.gov/mmwr/ preview/mmwrhtml/rr4910a1.htm. Published 2004. Accessed October 1, 2022.


40. Moderna. Making Strides Toward CMV Prevention. https://www.mod- ernatx.com/en-US/media-center/all-media/blogs/making-strides-toward- cmv-prevention. Published 2021. Accessed October 10, 2022.


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