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CONTINUING EDUCATION :: ANTIBODIES


Vitro Diagnostics EUAs — Serology and other adaptive immune response tests for SARS- CoV-2. https://www.fda.gov/medical-devices/ coronavirus-disease-2019-covid-19-emergency- use-authorizations-medical-devices/in-vitro- diagnostics-euas-serology-and-other-adaptive- immune-response-tests-sars-cov-2. Accessed October 13, 2021.


25. Bai Z, Cao Y, Liu W, Li J. The SARS-CoV-2 nucleocapsid protein and its role in viral structure, biological functions, and a potential target for drug or vaccine mitigation. Viruses. 2021; 13(6):1115. https://doi.org/10.3390/v13061115.


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27. Okba N, Müller MA, Li W, et al. Severe Acute Respiratory Syndrome Coronavirus 2−Specific Anti- body Responses in Coronavirus Disease Patients. Emerging Infectious Diseases. 2020;26(7):1478-1488. doi:10.3201/eid2607.200841. doi: 10.1371/journal. ppat.1008762.


28. Suthar M, Zimmerman M, Kauffman R, Ahmed R, Rodback J, et al. Rapid generation of neutral- izing antibody responses in COVID-19 patients. Cell Rep Med. 2020 Jun 23;1(3):100040. doi: 10.1016/j. xcrm.2020.100040.


29. Premkumar L, Segovia-Chumbez B, Jadi R, et al. The receptor binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients. Sci Immunol 2020;5(48):eabc8413. doi:


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30. U.S. Food and Drug Administration. Coronavirus (COVID-19) Update: FDA authorizes additional mono- clonal antibody for treatment of COVID-19. https:// www.fda.gov/news-events/press-announcements/ coronavirus-covid-19-update-fda-authorizes-addi- tional-monoclonal-antibody-treatment-covid-19. Updated May 26, 2021. Accessed: October 13, 2021.


31. McInstosh, K. COVID-19: epidemiology, virology, and prevention. UpToDate. uptodate. com/contents/covid-19-epidemiology-virology- and-prevention?search=tmab%20for%20 covid-19%20prevention&source=search_result& selectedTitle=3~150&usage_type=default&display_ rank=3#H1473330622. Revised October 6, 2021. Accessed October 29, 2021.


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34. Chi X, Yan R, Zhang J, et al. A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2. Science. 2020;369(6504):650- 655. doi:10.1126/science.abc6952.


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36. Earle KA, Ambrosino DM, Fiore-Gartland A, et al. Evidence for antibody as a protective correlate for COVID-19 vaccines. Vaccine. 2021;39(32):4423-4428. doi:10.1016/j.vaccine.2021.05.063.


37. LifeBridge Health. Research on rapid test to detect COVID-19 antibody levels. News Wise. August 18, 2021. https://www.newswise.com/ coronavirus/research-on-rapid-test-to-detect- covid-19-antibody-levels/?article_id=756067. Accessed October 29. 2021.


38. Robinson, L. Rapid test study could help doc- tors determine who needs COVID-19 booster shot. WBALTV11. Updated: August 19, 2021. https://www. wbaltv.com/article/rapid-test-study-covid-19- booster-shot/37351507#. Accessed October 29, 2021.


Jared Gresh, MT(ASCP) is a Technical Implementation Specialist at LumiraDx. He is a graduate of the medical technology program at Salve Regina University,


Brian K. DuChateau, PhD, D(ABMLI) is a board-certified clinical laboratory immunologist who received his PhD in immunology and medical microbiol- ogy from the University of


Wisconsin-Madison and completed a


post-doctoral residency in clinical immunology at the Chicago Medical School. With more than 20 years of experience as a clinical laboratory director and 12 years of in vitro diagnostics (IVD) experience, he currently serves as the LumiraDx Vice President of U.S. Scientific and Clinical Affairs.


14 DECEMBER 2021 MLO-ONLINE.COM


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