TABLETING
F AVANT-GARDE
ILLING TECHNOLOGY T
he recently launched robotic microdosing machine, the Macofar MicroRobot 50, is specially designed for fi lling potent and cytostatic medicines, for example for treating cancer and auto-immune diseases. T e technology is particularly suited for dosing sticky or hygroscopic pharmaceutical powders with irregular shapes. It can also be used to fi ll sterile liquids. For high containment applications up to level OEB 5, it can be supplied with isolator technology. Alternatively, it can be confi gured with cRABS or oRABS for non-cytotoxic products. During the production process, three
anthropomorphic robots transport the vials under an isolator to the dosing, stoppering and capping stations. Since the robots work independently of specifi c formats, the product change times are signifi cantly shorter. T e servo-driven transfer system generally reduces the concentration of particles in critical areas and with it the risk of contamination. Furthermore, thanks to the clearly structured system concept, the MicroRobot 50 is readily accessible and easy to clean. T e robotic grippers can be equipped with cleaning guns in order to validate the cleaning processes.
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A new microdosing machine is a high-tech solution for fi lling cytostatic powders into vials EACH VIAL IS INDIVIDUALLY
WEIGHED TWICE T e new solution achieves a maximum total output of 50 vials per minute including 100% in-process weight control; in other words, each vial is individually weighed both before and after fi lling. If necessary, the fi lling volume is adjusted automatically. Numerous control systems ensure a reliable process and a very low waste rate with these high-priced medicines. If a stopper is missing, for example, the fi lled vial is fed back to the station in question, where the process is repeated, rather than simply removed. T e same applies to missing caps; in case of missing rubber stopper/alu cap, the robot will go back to stoppering station/ alu capping station to correctly close the vials, reducing rejections.T e remaining quantity of the batch has been reduced to a minimum in the dosing station, so that product loss is virtually zero. T e ultra-compact machine is less than 4m long and was designed with ergonomic principles in mind. All product contact parts are extremely small and lightweight. T e use of components that are easy to remove and install was likewise a development priority. Access to the machine is via glove ports and RTP
systems. T e isolator features a built-in VHP generator for bio decontamination. T is is the fi rst Romaco Macofar
robotic fi lling and closing machine specifi cally designed to fi t under isolation technology. It equipped with two closing stations,
the fi rst one for rubber stoppers and the second one for alu-caps. It also off ers maximum accuracy when handling higroscopic powders. T ere is a high level of inertisation thanks to gassing points located on the robots’ arms, in the powder hopper and in the fi lling needles Washing can be performed by means
of robot, creating a validated cleaning process.
A JOINT DEVELOPMENT T e MicroRobot 50 unites the powder expertise of Romaco Macofar with Truking isolator technology. T is robotic microdosing machine represents the fi rst joint development project by the two pharmaceutical machinery specialists from Italy and China. Feedback so far has been altogether positive: orders for the MicroRobot 50 have already been received from two Asian pharmaceutical producers.
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