twice a day for 12 weeks increased im- munity, positively affecting neutrophil, monocyte and free radical production. In a clinical study of asymptomatic
children from 3 to 5 years old, treatment with beta glucans from reishi mushrooms showed increased immune system cells in the peripheral blood -- signaling a strong defense against childhood infections. Reviewing in vivo and in vitro studies on mice and human cell lines using lion's mane (Hericium erinaceus) and tiger tail (Trametes versicolor) mushrooms, treat- ments showed immunomodulatory, anti- cancer, anti-inflammatory and neurore- generative effects.
3. Antioxidant Polysaccharide beta glucan extracted from reishi mushroom was shown to be a powerful antioxidant in 37 high risk and 34 stable angina patients; those who were treated with 750 mg per day for three months had significantly decreased oxida- tive radicals and improved progression of atherosclerosis. In a study of 42 healthy subjects, an-
other intervention with beta glucan from reishi mushrooms of 225 mg per day for three months demonstrated its antioxida- tive effects -- enhanced total antioxidant capacity and enzyme activities as well as reduced mild fatty liver condition to nor- mal by suppressing oxidative stress were observed.
4. Anti-inflammatory Crohn's disease is a chronic inflam-
matory disease of the gastrointestinal tract. Treatment with a triterpene compound from reishi mushrooms showed that the inflammatory cytokines were significantly inhibited in a study of children with Crohn's disease.
Sixty patients with moderate persistent
asthma were studied and those who took the cordyceps sinensis mushroom capsule for two months had reduced airway in- flammation caused by their chronic asth- ma. Cordycepin from medicinal mush- rooms showed strong effects on many anti-inflammatory diseases. In a study of 32 patients with active rheumatoid arthritis, supplementation of medicinal mushroom and Chinese herbs -- reishi (4 grams) and San Miao San (2.4 grams) daily -- lowered arthritic pain for patients. The data in a mice study support a model where white button mushrooms regulate immunity in vitro and protect the colon from inflammation-induced injuries in vivo. The brain is susceptible to inflamma- tion as well. In an Alzheimer's disease model of rats, treatment with medicinal mushroom extracts delayed disease pro- gression, improved learning and memory functions and stopped neural cell deaths and brain atrophy.
Chaga mushrooms administered to mice successfully protected against Al- zheimer's disease by modulating oxidative stress, Nrf2 signaling and mitochondrial cell deaths while improving memory and cognition. Cordycepin from the Cordyceps sinensis mushroom alleviated Parkinson's disease motor disorder symptoms by low- ering oxidative stress and inflammation in vivo and in vitro.
Lion's mane mushrooms were supple- mented for 12 weeks and were effective in preventing dementia and cognitive decline Lion's mane supplementation for four weeks in a study of 30 females also reduced depression and anxiety.
5. Antidiabetic Dyslipidemia, high blood cholesterol
and triglycerides is often a harbinger of future diabetes. In a rat model, white but-
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Medicinal mushrooms are widely
researched and used as treatment in the prevention and progression of many dis- eases from cancer and asthma to diabetes and dementia. Mushrooms protect you due to their anti-inflammatory, antitumor, antidiabetic, immune boosting and anti- oxidant activities. To learn more, see GreenMedInfo.co
m's database on mush- rooms.
Written by Dr. Diane Fulton. © May 2021, GreenMedInfo LLC. This work is repro- duced and distributed with the permission of GreenMedInfo LLC. Want to learn more from GreenMedInfo? Sign up for the news- letter at www.greenmedinfo.co
ton mushrooms and a probiotic were found to lower dyslipidemia and decrease oxidative stress. In a study of 89 diabetic patients, oyster mushroom consumption significantly reduced blood glucose, blood pressure, triglycerides and cholesterol without ill effects on the liver or kidneys. Polyphenols from Phellinus igniarius,
or willow bracket, mushroom extract were used in vitro and in vivo studies of induced Type 2 diabetes mice and showed im- proved glucose tolerance, reduced hyper- glycemia and normalized insulin levels. Diabetic nephropathy, kidney disease
caused by Type 2 diabetes, was studied in vitro with disease-induced rats and treat- ment with Cordyceps cicadae resulted in improved insulin resistance and glucose tolerance, suppressed inflammation and balanced gut microbiome thus stopping the diabetes-related progression of renal disease and tumors. In an animal study, maitake mush-
room prevented the progression of kidney fibrosis in diabetic nephropathy rats, sig- nificantly decreased fasting blood glucose levels, reduced inflammatory cytokines and lowered renal fibrosis indexes indicat- ing its effectiveness in the treatment or prevention of nephropathy.
In their meta-analysis of 623 articles
and 33 randomized controlled experi- ments using cauliflower mushroom extract (S. Crispa), researchers found statistically significant differences in diabetic symp- toms including decreased serum insulin levels and wound rates and an increase in nutrient intake content.
Mushrooms and Their Medicinal Powers
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