in-cos Cat 30/3/09 17:58 Page 50
50 Advertorial
Mibelle Biochemistry discuss how a
herbal recipe for dry, sensitive skin
revealed strong anti-ageing effects
Traditional Chinese
o
l
u
m
e
medicine in personal care
Traditional Chinese medicine (TCM) is a holistic approach to healing that for inflammatory reactions in the skin and over time, they become a
began in China about 3000 years ago. The central elements of TCM, principal cause in normal and premature skin ageing. The oxidation of
acupuncture and herbal medicine has become very popular in Europe. A proteins is regarded to play a central role in cellular ageing because
recipe is typically a blend of several herbs and TCM is a highly respected oxidized proteins lose their activity and tend to form aggregates. The
means of treating skin disorders. In collaboration with an expert in TCM, sulphur-containing side chains of cysteine and methionine are the principal
Mibelle Biochemistry developed a herbal formula with anti-inflammatory and targets of protein oxidation. The TCM blend represents a means to prevent
soothing effects. The formula EpiCalmin TCM, comprising the aqueous protein oxidation and to regenerate existing oxidised proteins. EpiCalmin
extracts of Lonicera japonica flowers, Xanthium sibiricum fruits and Cyperus TCM was also found to strongly reduce the formation of extracellular matrix-
rotundus roots was designed to treat dry, sensitive skin. degrading enzymes. These enzymes perform the breakdown of collagen
The soothing and anti-inflammatory efficacy of EpiCalmin TCM was and elastin. Aged skin is characterised by an imbalance in the extracellular
demonstrated in a clinical study with 20 subjects using the anionic matrix: the biosynthesis of matrix components is reduced and their
surfactant sodium dodecyl sulphate (SDS) as the skin irritant. The resulting degradation is increased, resulting in a loss of elasticity and thinning of the
inflammatory response and its gradual disappearance were documented by skin. The results of the microarray show that EpiCalmin TCM has the
measuring skin hydration and redness. A cream containing 5 per cent of potential to counteract this tendency.
the TCM formula performed significantly better in the treatment of the A cosmetic blend based on 3000 years old Chinese medicinal knowledge
inflammatory response than a treatment with a placebo cream. was designed to treat dry, easily irritated skin. Its effects on skin cells were
In order to gain insight into the mechanism of the TCM blend, its effects analysed in a gene microarray experiment to measure 1300 relevant
on skin cells were analysed using the DNA microarray technology. It markers for skin disorders. The results demonstrate that EpiCalmin TCM
enables the measurement of the activity of a huge number of genes in a offers a strong anti-ageing potential.
single experiment. This particular array contained 1300 probes for genes
that are known markers for disorders in the skin barrier, the extracellular mibellebiochemistry
matrix, inflammation, signalling, DNA repair, skin cancer and others. Bolimattstrasse 1
EpiCalmin TCM was found to stimulate the cell’s own defence system 5033 Buchs, Switzerland
against oxidative stress by up-regulating the thiol-reducing enzymes
www.mibellebiochemistry.com
glutaredoxin and thioredoxin. Free radicals and oxidative stress are triggers Mibelle AG Biochemistry, Stand D600
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60 |
Page 61 |
Page 62 |
Page 63 |
Page 64 |
Page 65 |
Page 66 |
Page 67 |
Page 68 |
Page 69 |
Page 70 |
Page 71 |
Page 72 |
Page 73 |
Page 74 |
Page 75 |
Page 76 |
Page 77 |
Page 78 |
Page 79 |
Page 80 |
Page 81 |
Page 82 |
Page 83 |
Page 84 |
Page 85 |
Page 86 |
Page 87 |
Page 88 |
Page 89 |
Page 90 |
Page 91 |
Page 92 |
Page 93 |
Page 94 |
Page 95 |
Page 96 |
Page 97 |
Page 98 |
Page 99 |
Page 100 |
Page 101 |
Page 102 |
Page 103 |
Page 104 |
Page 105 |
Page 106 |
Page 107 |
Page 108 |
Page 109 |
Page 110 |
Page 111 |
Page 112 |
Page 113 |
Page 114 |
Page 115 |
Page 116 |
Page 117 |
Page 118 |
Page 119 |
Page 120 |
Page 121 |
Page 122 |
Page 123 |
Page 124 |
Page 125 |
Page 126 |
Page 127 |
Page 128 |
Page 129 |
Page 130 |
Page 131 |
Page 132 |
Page 133 |
Page 134 |
Page 135 |
Page 136 |
Page 137 |
Page 138 |
Page 139 |
Page 140 |
Page 141 |
Page 142 |
Page 143 |
Page 144 |
Page 145 |
Page 146 |
Page 147 |
Page 148 |
Page 149 |
Page 150 |
Page 151 |
Page 152 |
Page 153 |
Page 154 |
Page 155 |
Page 156 |
Page 157 |
Page 158 |
Page 159 |
Page 160 |
Page 161 |
Page 162 |
Page 163 |
Page 164 |
Page 165 |
Page 166 |
Page 167 |
Page 168 |
Page 169 |
Page 170 |
Page 171 |
Page 172 |
Page 173 |
Page 174 |
Page 175 |
Page 176 |
Page 177 |
Page 178 |
Page 179 |
Page 180 |
Page 181 |
Page 182 |
Page 183 |
Page 184 |
Page 185 |
Page 186 |
Page 187