FEATURE
Stockholm
Systems biology in nanosafety research
On the 9-10th November 2015, the Systems Biology in Nanosafety Research
conference took place at the Nobel Forum in Stockholm, Sweden. It marked the third in a series of mini-conferences on nanotoxicology, and was chaired by Professor Bengt Fadeel and Professor Juha Kere of the EU funded NANOSOLUTIONS project
S
ystems biology, defined as the computational and mathematical modelling of complex biological systems, is increasingly being applied in the field of nanosafety research for
observing and predicting the biological perturbations inflicted by exposure to engineered nanomaterials. The aim of this two-day meeting was to provide an overview of the state-of-the-art of systems biology approaches in nanosafety research. The conference was organised by Professor Bengt
Fadeel with Professor Juha Kere within the EU funded project FP7-NANOSOLUTIONS and in collaboration with the Working Group on Systems Biology in the EU NanoSafety Cluster, and took place at the Nobel Forum, which is part of the world renowned Karolinska Institutet. The meeting was the third event in a series of
miniconferences on nanotoxicology at the Nobel Forum organised by Professor Bengt Fadeel, the first of which was organised in 2006 and the second in 2010 in the context of the FP7-NANOMMUNE project. The 2015 meeting was the first meeting to focus specifically on systems biology, a topic that is of central importance for the FP7-NANOSOLUTIONS project. The project coordinator, Professor Kai
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Savolainen, provided the introductory remarks at the event. Dr Olli Ikkala presented the opening keynote lecture
oriented towards material sciences and emerging nanomaterial applications. In the closing keynote lecture Dr Martin Philbert foucsed on the increasing number and diversity of engineered nanomaterials, which necessitates more sophisticated approaches in toxicological testing. The invited lectures, with speakers from several
European countries, the US, Canada and China, were organised into sessions covering nanosafety, transcriptomics, proteomics, epigenomics and metabolomics, and bioinformatics. Highlights included Lucia Migliore’s talk on the epigenetic effects of nano-sized materials, as well as Brian Thrall’s lecture on the prediction of the biological effects of engineered nanoparticles on innate immune susceptibility mechanisms using integrated ‘omics. This international meeting was targeted at
academic scientists with an interest in systems biology and nanosafety research, as well as representatives from nanotechnology related industries and regulatory agencies. ★
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