EDITOR Tom Mulligan, MSc Tel: +44 1403 220755 Email:
tom@avakado.eu
SALES DIRECTOR Jaymin Amin, BEng Tel: +44 1403 220754 Email:
jaymin@avakado.eu
PUBLISHER Mark Harrington, BSc Tel: +44 1403 220753 Email:
mark@avakado.eu
PUBLISHING CONSULTANT Brian Cooper, MA, CEng
CHINA OFFICE Beijing Oriental Foreland Consultants Co, Ltd Tel: +86 10 84823421 Fax: +86 10 84846103 Email:
info@fair114.com Contact: Steve Qiao
SUBSCRIPTIONS Tel: +44 1403 220760
WEBSITE DESIGN Siric Communications Tel: +44 20 7193 6980 Email:
info@siric.com
WEBSITE
www.avakado.eu/dev/sp2-Magazine/Home
ANNUALSUBSCRIPTION £95.00 UK, £125.00 (US$250.00 or €185.00) overseas (includes postage) sp2
Inter-A Active is published six times a year:
January/February, March/April, May/June, July/August, September/October, and November/December by avakado media.
Published by avakado media, Global House, 13 Market Square, Horsham, West Sussex RH12 1EU. UK. Tel: +44 1403 220760 Fax: +44 1403 220761
©avakado media, 2012 ISSN 1476-184X
ABC Membership application approved
CPhI Worldwide 2012
Preview Issue
In this issue:
Process Development Medicinal Chemistry Outsourcing Biologics
September/October 2012
CONTENTS EDITOR’S PAGE NEWS
PROCESS DEVELOPMENT
4 6
16
Discovery and development: the new paradigm in outsourcing (Part 2) MEDICINAL CHEMISTRY
20
The ‘federated’ CRO model: delivering drug discovery expertise OUTSOURCING
Key strategies central to overcoming poor API solubility CUSTOM SERVICES
Manufacturing services support pharma development BIOCATALYSIS
Coupled chemoenzymatic reactions in continuous flow IZB MARTINSRIED/MUNICH
IZB companies: new drug development highlights BIOLOGICS
24 26 28 31 34
Developing cancer and infectious disease vaccines using mRNA PHARMACEUTICALS
38
Big Pharma: new technology and product licensing agreements EVENT PREVIEW
CPhI Worldwide: Madrid hosts UBM Live Pharma events 40
life science technology and business
www.avakado.eu sp2 Inter-A
Active brings you the
latest technology and industry updates in drug discovery, development, delivery and manufacture, with enhanced content that includes page links and video. Make the most of these new features by registering to receive the online publication.
September/October 2012 sp2 Inter-Active 3
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44