It’s even possible to test for genetic factors, defects of which are quite common, which play important roles in detoxification. With this information we can compensate for their negative effects with specific lifestyle and nutritional strategies.


In addition to performing a detox profile and genomic testing for


people in whom I suspect pathologic detoxification, I often perform a comprehensive nutritional evaluation for a full range of nutrients, including vitamins, fatty acids, antioxidants, minerals, and amino ac- ids, to more precisely target nutrient cofactor deficiencies and better support balancing of detox pathways.


A Classic Case of Pathologic Detoxification


“Diane S.”, as I’ll call her, came to see me after years of migrat- ing from one healthcare provider to another, none of whom had provided a definitive diagnosis or effective treatment for her growing list of symptoms and ailments. Diane had fatigue, recurrent head- aches, difficulty concentrating, joint pains, fibromyalgia, constipa- tion, difficulty sleeping, anxiety, depression – the list went on, and although standard lab tests revealed slight abnormalities associated with autoimmune activation, they did not point to a specific autoim- mune disease nor to any diagnosis that could explain her range of symptoms. Like many patients, she didn’t feel right, didn’t know why, and the inability to identify the reason caused great frustration and added to her distress. I told Diane that my diagnosis for her was “Diane S. Syndrome” –meaning that the underlying cause of her health issues was likely to emerge as a combination of functional systemic imbalances unique to her. Such a situation frequently eludes conventional diagnosis, until health has deteriorated to a point at which diagnostic crite- ria are met for a nameable pathology. A functional Detoxification Profile told us that Diane had high Phase 1 function and diminished function of two Phase 2 pathways, as well as poor conversion of the amino acid cysteine to sulfate, necessary for the healthy func- tion of the Phase 2 sulfation pathway. Diane was a classic patho- logic detoxifier. In addition, genomic testing revealed a genetic trait which causes impaired methylation, an important mechanism of toxin and biochemical metabolism (including the healthy elimina- tion of neurotransmitters which contribute to anxiousness); digestive analysis showed overgrowth of toxin-producing fungal species (yeast organisms); and nutritional testing showed deficiency of multiple B-vitamins, including folic acid and Vitamin B12, the trace mineral molybdenum, magnesium, and certain amino acids. It also showed indications of toxicity relating to heavy metals and styrenes, the chemicals used in production of many plastics and Styrofoam. With appropriate nutritional support, Diane soon began to have better en- ergy, focus, and sleep; her fibromyalgia improved and her joint pains and headaches lessened. When Diane supported her detox pathways with targeted nutrition, she was able to tolerate the work of diges- tive tract rebalancing, dietary change, and detoxification which were necessary steps to the ultimate resolution of her health problems.


Hope for the Pathologic Detoxifiers How can Phase 1 and Phase 2 learn to work together in harmo-


ny? A number of supplement formulations are specifically designed to provide broad support for Phase 2 reactions. Phase 2 co-factors include amino acids such as N-Acetyl L-Cysteine, Glutathione, Glycine, Glutamine, MSM (Methylsulfonylmethane), Taurine, Or- nithine and Methionine; B-vitamins, including folic acid, thiamine, riboflavin, niacin, pyridoxine/ pyridoxine 5-phosphate and vitamin B12; vitamin C; and minerals such as magnesium, manganese,


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