CNPerspectives
Pharmaceutical Outsourcing is one of several outstanding publications available from CompareNetworks, Inc. Here is a look at the insightful content our readers may enjoy from our sister publications: American Pharmaceutical Review, American Laboratory, Labcompare, and Biocompare.
Lifecycle Management for Near-Sterile Facility Contamination Control Programs
Regulatory expectations for microbial control in non-sterile manufacturing remain largely undefined, which is in contrast to well- defined expectations that exist for sterile manufacturing. This deficit is particularly evident for so-called “near-sterile” processes which demand particularly low levels of bioburden, effectively blurring the line between sterile and non-sterile processes. This article aims to affirm the importance of clearly outlining the strategy, rationale, requirements and measures of contamination control programs for these complex near-sterile systems, highlighting continuous improvement using a lifecycle management approach.
http://bit.ly/2fWXb42
High-Throughput Drug Screening of Multicellular Tumor Spheroids
Three-dimensional (3-D) culture models are increasingly being used for drug discovery in oncology, as they better represent the complexity of the in vivo microenvironment of solid tumors. By recapitulating cell-cell interactions, metabolic gradients and cell polarity, 3-D multicellular spheroids provide more physiologically relevant models than two-dimensional (2-D) cell culture. Despite these advantages, limitations of current technologies to enable simple and reliable assays have slowed the adoption of 3-D culture models for high-throughput screening (HTS).
http://bit.ly/2fHDoUT
The Automated Lab
Evolution of automation has moved beyond new technology to new levels of use. The use of automation covers academic and commercial labs, plus healthcare facilities. With the right instrumentation, automation makes science easier and more accurate, and often more economical.
http://bit.ly/2f3qNR
Advances in High-Content Imaging: 3D Cultures, Tackling Zika and More
High-content imaging systems enable researchers to measure more parameters and extract more data than is possible with conventional microscopy. High-content systems typically fall into one of two categories: those used for screening and those used for detailed analysis. High-content screening (HCS) systems offer sensitive measurements and high-throughput capabilities—and they examine as many samples as possible within an experiment. High-content analysis (HCA) systems may sacrifice some speed in the interest of obtaining even more complex, content-rich data.
http://bit.ly/2eomVFe Pharmaceutical Outsourcing | 8 | November/December 2016
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