chromatography • spectroscopy 27
preparative chromatography.
According to the company, Lux Cellulose-1 is one of the most successful chiral stationary phases on the market today. Te two cellulose- based phases add to a dependable, high-resolution screening set with a wide range of selectivity.
Te new 10-micron particles are available both in Axia-packed preparative columns, and in bulk, enabling customers to pack their own columns for the most cost- effective purification methods. Lux chiral phases Cellulose-1, -2, -3 and -4 are already offered in 20-micron bulk media for use in batch preparative and simulated moving bed chromatography.
Increased efficiencies Packing columns with new 10-micron particles delivers increased efficiencies by enabling the use of shorter columns without compromising results. Tis saves time and reduces solvent consumption.
Lux Cellulose phases benefit from Phenomenex’s novel manufacturing process and silica coating technology. Lux Cellulose-1 uses cellulose tris (3, 5-dimethylphenylcarbamate) as the chiral selector. Lux Cellulose-2 provides a second chiral selector, cellulose tris (3-chloro-4- methylphenylcarbamate), providing a unique chlorinated stationary phase with complementary selectivity to Lux Cellulose-1.
“Te demand for chiral preparative separations continues to grow in pharmaceutical R&D, as well as in toxicology studies,” explains Marc Jacob, product manager for Phenomenex. “Our Lux media have been very successful in resolving and identifying enantiomers and we are pleased to expand our offering to meet the needs of preparative chromatography applications.”
Phenomenex has also introduced Yarra, a new family of aqueous size exclusion chromatography (SEC) columns for biomolecule analysis. With years of R&D behind the
product technology, Yarra columns are engineered to provide efficiency increases of up to 70 per cent and much higher resolving power than other media.
Yarra columns, offered in three phases with three-micron particles, are ideal for the separation of small to large proteins and peptides, as well as biological therapeutics and biosimilars. Phenomenex proprietary hydrophilic surface chemistry ensures high resolution and minimal absorption of proteins for accurate quantitation.
Kieran Curley of US company Mannkind Corporation is one of the early users of Yarra. “I was very impressed with the Yarra SEC-3000 300 x 7.8mm column. It provided excellent resolution between the monomer and HMWP peaks, which allowed for consistent integration. Te peak shape was greatly improved for all sample components. We immediately revised our test method to include the Yarra SEC-3000 column,” he said.
“The demand for chiral preparative separations continues to grow in pharmaceutical R&D, as well as in toxicology studies.”
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