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DDW the quarterly business review of drug discovery & development


Publisher and Editor-in-Chief Robert Jordan Robert@rjcoms.com


Head of Digital Giles Jordan


Consultant Editor Dr Roger Brimblecombe


Design & Production Melissa Chadderton rhubarbcreative@sky.com


Editorial Advisors Dr Steve Arlington Dr Nigel Brown Dr Rathnam Chagaturu Dr David Clough Dr Richard Eglen Dr Gregory Lennon Dr Keith Mansford Dr Stephen Naylor Dr George Poste Dr Amber Salzman Dr David U’Prichard Dr Timothy Wells Dr Rene Ziegler


Drug Discovery World (ISSN 14694344) is published quarterly by RJ Communications & Media Ltd, 39 Vineyard Path, London SW14 8EL, United Kingdom. Tel: +44 (0)20 8487 5656 Fax: +44 (0)20 8487 5666 E-mail: Robert@rjcoms.com


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d r u g d i s c o v e r y wo r l d contents VOLUME 20 ISSUE 1 ●WINTER 2018/19


Introduction Dr Roger Brimblecombe Consultant Editor


Drug Discovery The Growth of Organoids in Cancer Drug Discovery – Will the Automated Expansion of Organoids Help Improve the Productivity of Cancer Drug Discovery? Dr Mark Treherne, Dr Marianne Ellis, Professor Trevor Dale, Dr Luned Badder and Dr Andrew Hollins


Lab Automation Faster, Smaller, Smarter – How Advanced Automation Liquid Handling Systems Are Reshaping Drug Discovery Helen Stewart-Miller and Dr Richard Massey


Cell Culture Optimising Clinical Leads: Increasing Drug Discovery Success With 3D Cell Culture Systems Dr Richard M. Eglen, Dr Feng Li and Dr Tony Frutos


Systems Pharmacology Perspective on Systems Pharmacology – When Multi-Targeting is Advantageous Dr Kirkwood A Pritchard Jr, Dr Dustin P Martin and Dr Stephen Naylor


Cell Culture Considerations for Engineering Composable, Disease-Tunable 3D Human Microtissues for Drug Discovery Dr Patrick Guye, Dr Eva Thoma and Dr Olivier Frey


Drug Delivery The Evolution of Transdermal Drug Delivery and Treating Migraine Dr Mahmoud Ameri and Hayley Lewis


Informatics Beyond SEND: Leveraging Non-Clinical Data to Drive Translational Research Forward. Katherine Briggs, Bob Friedman, Kristen Ferrara, Mark Pinches, Will Drewe, Cheryl Riel, Melody Thompson, Antoinette Hayes, Jason Gratt, Shylah Wyllie and MaryBeth Walsh


Business To GLP or not to GLP? – That is the Question…Knowing the Answer and Choosing the Right CRO May Save You Time and Money Scott Hickman, Dr Brian Ogilvie and Tim Patterson


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Front cover illustration courtesy of Sciepro/Science Photo Library Drug Discovery World Winter 2018/19 5


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