TECHNOLOGY IN ACTION ADVERTORIALS
ADVERTORIALS
In the pharmaceutical industry, emulsions are a key component in many formulations and products. Emulsions are used in the manufacture of pharmaceutical creams and lotions through to more complex applications such as adjuvants to improve the immune response to the antigens used in vaccinations. Whether it is a Water-In-Oil (W/O) emulsion or an Oil-In-Water (O/W) emulsion, getting the emulsion to remain stable in order to deliver the desired results - e.g. improved immune response - can be a challenging task. Whichever type of emulsion you are manufacturing, and for whichever product, the goal is the same: The globule size needs to the mixer is stopped, the phases remain combined and don’t begin to separate.
possible droplet size. The more shear energy introduced into the mix, the smaller the droplets will become. As such, high shear rotor/stator mixers are advantageous for creating stable emulsions. Silverson high shear mixers can easily achieve emulsions with a globule size of 2 to 5 microns. Finer emulsions down to 0.5 microns can be obtained, depending on the formulation. This is achieved as follows:
effect on the droplet size. So even though it may appear visually that the two phases have been combined, after time they will begin to separate. Separation of the emulsion is to be avoided as this can affect the shelf-stability, product quality and can even make products such as adjuvants unusable due to inconsistencies between batches. So while conventional mixing equipment like stirrers and agitators
Some types of mixing equipment, such as stirrers and agitators,
the large globules from both phases are drawn by the high speed rotation of the rotor blades into the centre of the workhead. The globules are driven towards the workhead periphery by centrifugal force where they are subjected to a milling action in the narrow gap between the rotor blades and the inner wall of the stator. The globules are then subjected to additional high shear energy by being forced at high velocity through the stator perforations – in this case an emulsor screen, an interchangeable workhead which is available for all Silverson mixers. The smaller droplets are expelled radially from the workhead into the bulk of the emulsion, where the mixing cycle continues until the targeted droplet size and stability are achieved.
Silverson
sales@silverson.co.uk www.silverson.co.uk
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https://www.dualpumps.co.uk/ https://www.dualpumps.co.uk/catalogue-request OCTOBER 2022 | PROCESS JANUARY 2021 | PROCESS & CONTROL 59
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