Contents In this issue 18 6 Numbers


The headlines and vital statistics impacting healthcare.


Diagnostics


8 CRISPR-based detection The discovery of CRISPR was a pivotal moment in the field of genetic engineering, due to the ability to use it to enable site-specific editing of DNA. It’s been a decade since CRISPR was discovered and this particular application still hasn’t made it out of clinical trials and into the clinic. But that doesn’t mean the tool doesn’t have its uses, as we discovered when a plethora of CRISPR-based Covid-19 tests hit the market during the pandemic. Covid-19 is just a single use case for CRISPR in diagnostics, however, and Oladimeji Ewumi speaks to Bryan Dechario, CEO of Sherlock Biosciences, and Kevin Davies, executive editor of The CRISPR Journal, to learn how the genetic engineering tool is being used to develop improved testing protocols for diseases.


13 Fighting healthcare-associated infections


Bruker Microbiology & Infection Diagnostics


15 Optimise lab workflows with the right assay kits Uniogen


4 Practical Patient Care / www.practical-patient-care.com


17 Unique test spectrum for neural autoantibodies EUROIMMUN


18 A softer approach to brain monitoring


Abnormal brain activity can be a tell- tale sign of neurological disease, but detecting it is more of a marathon than a sprint. Several limitations, from technology to convenience, prevent clinicians from detecting the signals needed to make a diagnosis, and the result is that patient treatment is delayed. There could be a glimmer of hope for the long-term monitoring necessary to avoid these mistakes,


30


however. Sophie Ash speaks to Jennifer Gelinas, assistant professor of neurology, electrical, and biomedical engineering, and director of the Epilepsy and Cognition lab at Columbia University Irving Medical Center, to find out how developments in materials science could make constant monitoring a reality for doctors and patients.


22 Addressing latent TB infection in the immunosuppressed Revvity


27 In the MIC of time to fight antimicrobial resistance Q-linea


Wound care 30 Keeping tabs


One of the key components of effective wound management is keeping track of indicators that drive wound pathology and healing. Typically, this is done by assessing how they look and sending swabs to the lab. But there’s a better way on the horizon, and it comes in the form of new technologies that can quickly analyse the state of a wound and allow practitioners to expedite treatment and give patients the best chance to heal. Allison DeMajistre speaks to Benjamin Tee, associate professor at the Department of Materials Science and Engineering


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