NEWS
Extended range of violet and ultraviolet dyes for flow cytometry
Bio-Rad Laboratories has extended its range of StarBright dyes to include StarBright Violet 760, StarBright UltraViolet 575 and StarBright UltraViolet 605 dyes, offering improved brightness with narrow excitation and emission profiles.
The Bio-Rad range of StarBright Dyes
provides researchers with highly stable, validated flow antibodies conjugated to proprietary fluorescent nanoparticles and specific to key immunophenotyping targets, supporting multiplex flow cytometry panels in immunology research. Minimal lot-to-lot variation ensures reproducible and consistent staining, and the dyes are resistant to photobleaching and do not lose signal in fixation.
The dyes, excited by violet (405 nm) and ultraviolet (355 nm) lasers, are compatible with the Bio-Rad ZE5 Cell Analyser and S3e Cell Sorter, as well as most flow cytometers and a variety of experimental protocols, without the need for special buffers.
“The continued expansion of the Bio-Rad StarBright Dye portfolio, currently totalling 17 dyes, nine of which are StarBright Violet Dyes, gives researchers greater flexibility and choice when designing flow cytometry panels, by providing high-performance dyes excitable at a range of wavelengths,” said Dr Mike Blundell, Bio-Rad Product Manager, Flow Cytometry, Life Science Group.
The exceptional brightness and unique
profile of the dyes delivers enhanced resolution of rare populations and low- density antigens.”
www.bio-rad-antibodies.com/flow-
cytometry-starbright-dyes.html
Point of Care: Innovations meeting – the confirmed programme
‘Point of Care: Innovations’ is a free-to- attend meeting for NHS staff being held in Bristol at The Bristol – Harbourside (Doyle Collection) hotel on 20 September. This all- day event will be supported by 26 vendors from the POCT and rapid diagnostics space, and will include presentations about current and future POCT themes. The full programme can be download (https://
assets.stepcomms.com/pip/Agenda_-_ POCT_Innovations.pdf), and further
8
information is also available online.
https://poctinnovators.com/
Automated dried spot sampling and analysis system
Thermo Fisher Scientific enables clinical research, toxicology and anti-doping laboratories performing dried spot sampling and analysis to utilise a new automated sample preparation and ultra- high-performance liquid chromatography (UHPLC) system. The new Thermo Scientific Transcend DSX-1 integrated sample preparation and UHPLC system eliminates disc punching typically associated with dried matrix (spot) cards, and optimises sample extraction and recovery of multiple matrices (eg blood, urine, serum and saliva). The new system enables laboratories performing routine analysis of drugs and other compounds to achieve substantial savings on time, labour and reagent costs compared to manual workflows. Proprietary flow-through desorption with heated capillary eliminates the need for manual, time-consuming extraction protocols and the automatic addition of an internal standard prior to the extraction minimises matrix interference. Robustness and sensitivity are enhanced through online proprietary sample clean-up and enrichment via Thermo Scientific TurboFlow technology, producing confident results. “Toxicology laboratories play a crucial
role in detecting drug use and misuse in an ongoing struggle to safeguard society against increasing numbers of substances at ever-decreasing concentrations. Dried spot analysis has emerged as a key technology in this area, requiring only a small amount of sample and, therefore, minimising the user impact,” said Brad Hart, senior director, analytical vertical and life science mass spectrometry marketing, Thermo Fisher
Scientific. “With the conventional workflow being held back by time-consuming manual procedures, we designed the Transcend DSX-1 system to ensure laboratories are able to increase throughput to meet demand, while still ensuring the integrity and quality of results that are expected.” Professor Mario Thevis, director for the Center for Preventative Doping Research, German Sport University, Cologne, said, “Dried blood spot (DBS) tests have the potential to contribute substantially to an improved anti-doping testing programme, today and in the future, supporting the clean athlete as well as the overall doping control analytical strategy. DBS analysis is the latest tool approved by the World Anti-Doping Agency (WADA) and was introduced at this year’s Winter Olympic Games in Beijing, China. In order to accommodate the specific needs associated with DBS analyses, and the considerable number of target analytes, robust, sensitive, programmable and especially automated DBS analytical options will offer critical advantages to anti-doping laboratories.”
www.thermofisher.com/TranscendDSX
SEPTEMBER 2022
WWW.PATHOLOGYINPRACTICE.COM
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