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FEED ADDITIVES ▶▶▶


Table 1: Newcastle disease virus shedding after challenge with a genotype VII virulent virus via different challenge routes.


Cloacal-Swab


Humoral immunity of chickens was improved by increasing antibody titers against Newcastle disease virus through ap- plication of the natural herbal medicine.


Results At 4 days of age (before starting the treatment), the mean an- tibody titers in all groups were equal to 5.14 as maternal anti- body titer. Also, the antibody titer was not significantly differ- ent in the control groups up to 35 days of age (before the challenge with the virus). At 21, 28 and 35 days of age, the antibody titers in the vaccinated groups were higher than those in the control groups, and the groups treated with Im- muno Propophyt showed the highest antibody titers (p<0.05); so that the antibody titers in group A and B were about 1 log2 higher than group C and D on day 35. The re- sults of shedding analysis following virus challenge in the dif- ferent groups are shown in Table 1. In the control group where the challenge was carried out through injection (group E), clinical symptoms appeared from day 2 after challenge and all chicks died on day 3; their cloacal and tracheal sam- ples showed virus shedding. In the contact-challenged con- trol group (group F), symptoms appeared from day 5 after challenge and all birds died by day 10; the results showed that 67% of cloacal and 100% of tracheal samples were posi- tive for virus shedding, on day 7. In this group, only two birds were alive on day 10 after challenge, which both of them showed virus shedding in their samples. Following the


22 Groups


A 0 0 0 0 B 0 0 0 0 C 0 0 0 0 D 0 0 0 0 E 100%


- F 0 67% - 100% Tracheal-Swab


Day 3 PC Day 7 PC Day 10 PC Day 3 PC Day 7 PC Day 10 PC 0 0


100% 10%


30% 0 -


100%


0 0 0 0 -


50%


PC: Post challenge, A: Treated and vaccinated group challenged by intramuscular route, B: Treated and vaccinat- ed group challenged by contact, C: Vaccinated group


challenge through injection on treatment groups, 30% of tra- cheal swabs in group C showed virus shedding on day 7 after challenge, while no positive sample were observed in others. All birds in the vaccinated groups A to D were protected com- pletely and no morbidity or mortality occurred.


Improved immunity The results indicate that the humoral immunity of chickens was improved by increasing antibody titers against Newcastle disease virus through the application of the natural herbal medicine (Figure 1). Also, when chickens were challenged with virulent NDV, this natural herbal extract prevented the replication and shedding of the virus. As a result, we conclude that using this natural herbal medicine could improve vaccine immunogenicity and reduce shedding from vaccinated birds exposed to vNDV.


▶ ALL ABOUT FEED | Volume 28, No. 3, 2020


PHOTO: PENTALUX


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