NEWS


16-18 April PACK EXPO East 2018 Packaging innovation for food, beverage, pharmaceutical / medical device, cosmetic/personal care, chemical/household and other packaged goods. Philadelphia, Pennsylvania, US packexpoeast.com


16-18 April 22nd Topical Meeting of the International Society of Electrochemistry Materials engineering and process optimisation at electrified solid- liquid interfaces. Tokyo, Japan topical22.ise-online.org


18-19 April Polymers in Building Insulation Trends, challenges and opportunities for the construction industry in relation to thermal and acoustic insulation. Cologne, Germany ami.international/events


19 April CDOIF Environmental Tolerability Training on the Chemical and Downstream Oil Industries Forum published guidance for determining the tolerability of environmental risk at COMAH establishments. London, UK cia.org.uk/Training-and-events


23-25 April Microbial stress: from systems to molecules


New methodological and scientific approaches from microbiologists, biotechnologists, system biologists, biochemists and molecular biologists. Kinsale, Ireland efb-central.org/index.php/ microbial_stress


23-26 April Analytical Data Analysis for the Bioprocessing Industry Understand how to manage analytical data and its relevance to process and product. London, UK


ucl.ac.uk/biochemeng/research/


mbi/courses 23 April


What a Chemist needs to know about Patents Reg: 09:00 Start: 09:30 Organised by SCI’s Young Chemists’ Panel SCI, London, UK +44 (0)20 7598 1561 conferences@soci.org


24 April 29th Regional Postgraduate Symposia on Novel Organic Chemistry - North Reg: TBC Organised by SCI’s Fine Chemicals Group Newcastle University, UK +44 (0)20 7598 1561 conferences@soci.org


24-25 April MENA New Energy PV, concentrated solar power, wind and energy storage in Middle East and North Africa. Dubai events.newenergyupdate.com/


mena/


25-26 April 8th European Algae Industry Summit Developments in cosmetics, food, feed, nutraceuticals and pharmaceuticals. Vienna, Austria wplgroup.com/aci/event/


european-algae-industry-summit 25-26 April


Chemspec India 2017 Exhibition for fine and specialty chemicals, a networking platform for domestic and international buyers and sellers. Mumbai, India chemspecindia.com


25-26 April Mediadata Next – London Network with industry experts in drug and device development, clinical operations, data management, biostatistics and digital medicine innovation. London, UK medidatanext.com


26 April CLP for Formulators and Importers – An Introduction Understand principles/ requirements of the Classification, Labelling and Packaging (CLP) Regulation to make sure your labels and SDS are correct and compliant. Manchester, UK cia.org.uk/Training-and-events


14-15 May Kinase 2018: towards new fron- tiers - 8th SCI / RSC symposium on kinase inhibitor design Start: Reg: 09:30 Start: 10:00 Organised by SCI’s Fine Chemicals Group and RSC’s Biological and Medicinal Chemistry Sector Babraham Research Campus, Cambridge, UK


+44 (0)20 7598 1561 conferences@soci.org


15 May Innovation in design and acquisition for Compound Screening Libraries Reg: 08:30 Start: 09:00 Organised by SCI’s Fine Chemicals Group and the Academic Drug Discovery Consortium (ADDC) Benjamin Franklin Institute of Technology, Boston, USA +44 (0)20 7598 1561 conferences@soci.org


10-12 September 7th SCI/RSC Symposium on GPCRs in Medicinal Chemistry Start: TBC Organised by SCI’s Fine Chemicals Group and RSC’s Biological and Medicinal Chemistry Sector Aptuit, Verona, Italy +44 (0)20 7598 1561 conferences@soci.org


16-18 September Electrochem 2018 Start: TBC Organised by SCI’s Electrochemical Technology Group, RSC’s Electrochemistry group and RSC’s Electro- analytical & Sensors Group Lancaster University, UK +44 (0)20 7598 1561 conferences@soci.org


24-25 September A Celebration of Organic Chemistry 2018 Start: TBC Organised by SCI’s Fine Chemicals Group UCB, Braine, Belgium +44 (0)20 7598 1561 conferences@soci.org


Date TBC


Engineering Synthetic Diamond for Technological Applications Reg: 18:00 Start: 18:30 Organised by SCI’s London Group in partnership with Marks & Clerk Marks & Clerk, London, UK communications@soci.org


event review


Can protease inhibition offset insecticide resistance?


As with many pest, weed and disease organisms, insect pests present continuing problems in agriculture, and their management with insecticides can give rise to resistant strains that are increasingly difficult to control. This problem of resistance is becoming critical, especially for the control of vectors of public health concern. This is exacerbated due to the limitations on the introduction of new effective and safe insecticidal types and increasing concerns on environmental and human toxicology aspects. As a consequence, considerable effort


has been expended in understanding how insects and related pests become resistant. Here, SCI highlights how new understanding of these processes could influence crop pest management and potentially many other areas. Traditionally, resistance mechanisms


have been explained by changes at the molecular level, such as enzyme inhibition and enhancement, and at the organelle or tissue levels, such as nerves or membranes. The rapid application of molecular


biology methods – especially transcriptomics – has revealed changes that occur when insects are exposed to insecticides or become adapted to survive in such stressful environments. Any stimulus detrimental to an insect


stresses its constituent cells. The insect response to toxins is no different. The careful dynamic balance of the cell is perturbed and this balance or homeostasis needs to be recovered if the insect is to survive. The major components in the cell that maintain proteostasis are the intracellular proteases, which interact with the protein synthesis machinery. Stress in the cell results in oxidised


or misfolded proteins, which need to be removed. These undesirable proteins are hydrolysed by intracellular proteases, especially the proteasomes, and the resulting peptides and amino acids are recycled to produce the building blocks to make defensive systems. Thus, it is likely that the role of proteases is to help prepare the cell to protect it against stressors, rather than provide a de facto resistance mechanism. This topic was the subject of a


presentation made to a meeting SCI’s Agrisciences group in September 2017. Read the full article here: bit.ly/2EI1t6Y


02 | 2018 17


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