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Drug Fingerprinting via Unique HPLC/MS Salt Forms Method
Thermo Fisher Scientific announce that it has developed a comprehensive method for the identification, confirmation and quantitation of illicit drugs and their salt forms. This unique method combines high- performance liquid chromatography with mass spectrometry (HPLC/MS) to provide accurate simultaneous separation and detection of cations and anions in illicit drug salt forms. The technique enables drug salt forms to be precisely identified and confirmed by two independent parameters - retention time and mass spectral signature, allowing forensic drug chemists to reliably analyze seized materials. The method also enables pharmaceutical drug QA/QC analysts to determine counterfeit drugs and describe drug efficacy. The new method is detailed in an application note entitled “An Accurate and Robust LC/MS Method for the Identification of Illicit Drug Salt Forms.” It is available free via
www.thermoscientific.com/salt.
The World Drugs Report 2009 states that between 172 and 250 million people worldwide used illicit drugs at least once in 2007, with 18–38 million estimated to be heavy drug users. The illicit drug trade fuels crime and violence and inappropriate and extended use of any of these drugs can lead to devastating health outcomes. Illicit drugs are often encountered in the form of salts and identification of the specific counterion present may provide valuable information about the source of production and the manufacturing pathway. As a result, techniques to accurately screen and identify
drugs, drug precursors and new drug derivatives are crucial to law enforcement efforts to curb the black market in controlled substances.
The new Thermo Scientific HPLC/MS method is a powerful alternative to other techniques currently being used to analyze illicit drugs and their salt forms. This method enables simultaneous determination of cations and anions with exceptional sensitivity, detection and accurate identification of a wider range of compounds without requiring derivitization, which in turn provides simultaneous qualitative and quantitative information on drug salt forms.
In this method, HPLC/MS analysis is performed on a Thermo Scientific Accela UHPLC system coupled to a Thermo Scientific MSQ Plus Mass Detector, a sensitive and fast scanning single quadrupole mass spectrometer. The Accela™ UHPLC system offers the flexibility of performing both conventional and high- speed LC separations on a single platform, while the rapid polarity switching capability of the MSQ™ Plus Mass Detector, together with its operational mass range, enables simultaneous detection of cations and anions in a single analysis.
E-mail
analyze@thermofisher.com or visit
www.thermoscientific.com/accela
Gas Chromatography App on the App Store
Agilent Technologies, Inc announced that a GC Calculator App is now available on the App Store. The GC Calculator is a first-of-its- kind gas chromatography app for the iPhone and iPod touch. The GC pressure and flow calculator app can be used to instantly and accurately determine pressures and flows through open tubular capillary columns. The app is based on the popular PC version that has been downloaded more than 10,000 times from the Agilent website.
“Agilent continues to provide innovative solutions to help our customers drive productivity,” said Anne Jones, Vice President of Agilent’s Chemistries Division. “Our customers can use this practical and convenient app anywhere and at anytime to quickly see how different GC conditions will
affect their column flow and pressure before setting up their system.”
The GC Calculator App is available free of charge from the App Store on iPhone and iPod touch. Agilent GC Calculator works with iPhone 4, iPhone 3G, the original iPhone, and iPod touch.
Agilent introduced an LC Calculator App earlier this year, also available free of charge from the App Store, which includes hundreds of Agilent column configurations and other method parameters to improve chromatography. Scenarios can be quickly formed and compared with a simple tap or swipe on the innovative multi-touch user interface to discover what combination of parameters work best to increase analysis speed and lab productivity.
For more information visit
www.agilent.com NACALAI TESQUE, INC.
E-mail :
info.intl@
nacalai.com Web :
www.nacalai.com
Hichrom Ltd - Authorised UK Distributor
E-mail :
sales@hichrom.co.uk Web :
www.hichrom.co.uk Tel : +44 (0)118 930 3660
COSMOSIL 2.5C18-MS-II18 Low back pressure (2.5 µm silica gel)
Multi-purpose monomeric C18
COSMOSIL 2.5Cholester Cholesterol bonded stationary phase
COSMOSIL 2.5Cholester Low back pressure (2.5 µm silica gel)
Excellent molecular shape selectivity COSMOSIL 2.5NAP New!
Low back pressure (2.5 µm silica gel) Naphthalene bonded stationary phase Stronger - interactions than Phenyl columns
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