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December 2010 New HPLC Column Line
enhanced separation and peak shape of basic compounds under neutral and acidic pH conditions. In comparison studies with other C18 columns, this new Kinetex phase has produced differences in peak elution order and improved separation of co-eluting compounds.
Phenomenex Inc. announce the addition of two new phases in its successful Kinetex core-shell HPLC/UHPLC column family. Kinetex XB-C18 and Kinetex C8 bring the advantages of ultra-high liquid chromatography performance (UHPLC) within standard HPLC operating pressures to a growing list of applications. Kinetex core- shell technology meets researchers’ need to improve results and increase productivity without large capital expenditures.
The new Kinetex XB-C18 provides a unique selectivity, incorporating two iso-butyl side chains at the base of the C18 ligand to reduce secondary interactions with residual silanols. These columns deliver
UHPLC hardware meets DryLab software
Shimadzu cooperates with the Berlin/Germany based Molnár- Institute in applying the new DryLab 2010 software and the new generation of Shimadzu UHPLC instruments. QbD automated HPLC Method Development using DryLab 2010 enables the transfer of HPLC methods into most-modern Shimadzu UHPLC technology. By remaining in the design space, much higher flexibility is achieved in adjusting working conditions according to individual needs.
Perfect fit with Shimadzu’s LabSolutions software DryLab 2010 and Shimadzu’s LabSolutions software complement each other perfectly. LabSolutions provides a platform for all of Shimadzu’s chromatographic systems. Even 3D detection technologies are covered. DryLab 2010 targets method development and applications to run under regulated environment with a special focus on the pharmaceutical industry. The software’s reliability rate is
Simplified Determination of
2-Ethylhexanoic Acid in Clavulanate Dionex is proud to announce a simplified method for the detection and quantification of 2-ethylhexanoic acid, a potential impurity in potassium clavulanate active pharmaceutical ingredient (API) incorporated during sample purification. Application Note 262: Determination of 2-Ethylhexanoic Acid Impurity in Clavulanate reports results for limit of detection/limit of quantification (LOQ/LOQ), linear calibration range, spike recovery, retention time precision, and peak area precision determinations that show this to be an accurate and reproducible technique to determine 2-ethylhexanoic acid in clavulanate below the 0.8% acceptance criteria.
The determination method outlined in Application Note 262 uses a Dionex Reagent-Free™ Ion Chromatography (RFIC™) system and direct injection onto an IonPac® AS11 column without additional sample pretreatment. This approach uses 150-fold
lower concentration of the API and eliminates the need for solvent extraction per the current United States Pharmacopeia (USP) monograph, thus consuming less of the API and simplifying sample preparation.
For more information visit www.dionex.xom
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percent.More than 106 experiments can be modelled based on a set of 12 basic experiments under pre-defined conditions.
For most chromatographic applications in the lab DryLab 2010 now enables simultaneous optimization of several measured experimental parameters (tG, T, pH, ternary composition of eluent B, buffer or additive concentration) with 9 other derived factors (column length, -ID, particle size, flowrate, %B(start), %B(end), gradient steps, dwell volume, extra column volume) to further define the Design Space of a separation. The 3D Cube is calculated based on 12 experiments using 3 gradient time- temperature (tG-T) models with one additional factor and it represents over one million modelled chromatograms and evaluates multiple parameters simultaneously.
For more information visit
www.shimadzu.com
The new Kinetex C8 phase meets the United States Pharmacopeia (USP) specifications for Classification Code L7, enabling laboratories using L7 columns to realize the benefits of Kinetex core-shell technology while staying compliant with USP-allowable adjustments.
“We introduced our revolutionary Kinetex core-shell technology one year ago, and the market response and adoption rate have exceeded our expectations,” comments Jeremy Bierman, brand manager for Phenomenex. “We’re pleased to add these two new phases to the three we initially offered. Our product development team will continue to bring even more core-shell resources to the chromatography field.”
The new Kinetex core-shell columns are available in two particle sizes – 2.6- and 1.7- micron – and in variety of column dimensions.
For more information visit
www.phenomenex.com
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