search.noResults

search.searching

note.createNoteMessage

search.noResults

search.searching

orderForm.title

orderForm.productCode
orderForm.description
orderForm.quantity
orderForm.itemPrice
orderForm.price
orderForm.totalPrice
orderForm.deliveryDetails.billingAddress
orderForm.deliveryDetails.deliveryAddress
orderForm.noItems
6 The Hampton Roads Messenger1 The Hampton Roads Messenger Our Health


Flu infection study increases understanding of natural immunity


Volume 12 Number 5


Volume 12 Number 3 Healthy Recipe 1 pound lentils


3D print of hemagglutinin (HA), one of the proteins found on the surface of influenza virus that enables the virus to infect human cells. In this model, blue and purple denote areas where mutations can change the ability of the virus to attach to host cells and cause infection.


BY NATIONAL INSTITUTES OF HEALTH


antibodies against the stem portion of


People with higher levels of the influenza virus hemagglutinin


(HA) protein have less viral shedding when they get the flu, but do not have fewer or less severe signs of illness, according to a new study published in mBio. HA sits on the surface of the influenza virus to help bind it to cells and features a head and stem region. Scientists only recently discovered that humans naturally generate anti-HA stem antibodies in response to flu infection, and this is the first study of its kind to evaluate pre-existing levels of these specific antibodies as a predictor of protection against influenza. Te findings could have implications for flu vaccine development, according to the authors. Scientists at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, conducted the research.


Te study immune responses


team has explored to two influenza


surface proteins: HA—the main target of traditional seasonal flu vaccines— and neuraminidase (NA). Te head region of HA is constantly changing, which is why influenza vaccine strains must be updated each year. Te HA stem region, however, is less susceptible to change, making it a potential target for novel vaccines aimed at broader, more durable protection.


sought


In the new analysis, investigators to understand the role of


pre-existing anti-HA stem antibodies in protection against influenza using data from a healthy volunteer influenza challenge trial that took place in 2013 at the NIH Clinical Center in Bethesda, Maryland. Led by NIAID’s Matthew J. Memoli, M.D., the trial enrolled 65 healthy volunteers aged 18 to 50 years. Participants stayed in a specially designed isolation and infection control unit throughout the study. Investigators measured participants’ baseline levels


of anti-HA stem antibodies, infected them with a 2009 H1N1 influenza virus, and then measured levels of anti-HA stem antibodies again.


Tey found that all volunteers


had anti-HA stem antibodies at baseline, although levels varied, and 64 percent of participants had increased levels aſter infection. However, people with higher levels before exposure had smaller increases, suggesting there could be a limit that humans can achieve naturally. Trial investigators also closely monitored participants’ symptoms and the amount of influenza virus they shed from the nose, which may indicate how contagious someone is. Similar to findings regarding anti-HA head antibodies, they found that participants with


higher baseline


levels of anti-HA stem antibodies had reduced viral shedding, but no significant reduction in the duration or severity of illness.


naturally


Te results show that people make


anti-HA stem


antibodies, but that responses vary significantly, and also these antibody levels are not independent predictors of whether someone becomes sick or if so, how severely. Te authors note that antibodies against NA remain the only identified predictor of disease severity, according to previously reported trial data.


Although the data are limited,


the results have implications for novel influenza vaccine design, according to the authors. Tey note future strategies ideally should focus on more than one aspect of immunity. “Careful consideration of the complexity of influenza immune protection and evaluation of all aspects of the anti-influenza immune responses will ultimately be necessary in the development of a successful broadly protective or universal influenza vaccine,” the authors said.


2 boxes vegetable stock (32 fl oz) 1 large can crushed tomatoes (28 oz) 2 garlic cloves, diced 2 onions, diced 4 tbsp. curry powder 1 tbsp. turmeric 2 tsp. fenugreek 3 dried curry leaves 2 tbs. minced ginger 2 jalapenos, diced 2 tbs. sugar


vegetable oil, salt, pepper to taste


Sauté the onion, garlic and curry leaves in a large stockpot over medium- high heat until the veggies turn translucent.


Add the jalapenos and continue to sauté for 10 minutes.


Rinse the lentils thoroughly; running your fingers through the lentils to make sure that there is no grit or bad lentil hiding in there.


You can pick out any “bad” lentils you see, but you mostly just want to rinse the lentils until the water runs clear. Now add all of your dry spices. Remove the curry leaves and discard. Add the can of crushed tomatoes. Add the vegetable stock.


Add the lentils. Turn up the heat to bring the mixture to a boil and then reduce the heat to medium and let the dish simmer for 30 minutes, or until it has thickened considerably and the lentils are tender.


LIVE your life. Let US fight your cancer.


Proton Therapy... No Hospital Stays! • Non-invasive • Precisely targets tumor • Healthy tissue spared • Reduced side effects • Treatment time less than two minutes


• FDA approved and covered by Medicare, Medicaid and most insurance providers


“I’m feeling great after treatment. I didn’t have any side effects, no energy loss. I continued my daily routine. Nothing changed. Proton therapy was the best option for me.”


TREATING BREAST, LUNG, PROSTATE, HEAD & NECK, GI, BRAIN & SPINE AND PEDIATRIC CANCERS Learn more: Give us a call today.


757.251.6800 • hamptonproton.org 40 Enterprise Parkway, Hampton, VA 23666


Lung Cancer Awareness Month


Healthy Recipe Indian Spiced Lentil Soup


Try this lentil soup with curry powder, tumeric, ginger, jalapenos, and crushed tomatoes for a vegan soup recipe.


February 2018


December 2017


- James Burton Lung Cancer Survivor Yorktown, VA


Page 1  |  Page 2  |  Page 3  |  Page 4  |  Page 5  |  Page 6  |  Page 7  |  Page 8  |  Page 9  |  Page 10  |  Page 11  |  Page 12  |  Page 13  |  Page 14  |  Page 15  |  Page 16