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MRC Centre for Developmental and Biomedical Genetics

The MRC Centre for Developmental and Biomedical Genetics (CDBG) is a flagship partnership between the Faculties of Science and Medicine, Dentistry and Health. Internationally-recognised as a leading centre for Biomedical research, the CDBG combines expertise from both Faculties to create a unique, critical mass of investigators addressing major health burdens such as chronic inflammatory disease, cancer, dementia and heart disease. Its key strategy is to bring together developmental geneticists with clinician scientists, creating a focus of expertise in the generation of animal models of human disease, with the goal of promoting the translation of findings from model systems to clinical practice through the identification and development of novel therapeutics. Led by Professor Philip Ingham, FRS, the CDBG is a key driving force in the delivery of translational research for both Faculties and boasts some of the finest research facilities in the UK. It currently attracts annual grant income in excess of £2 million.

Non-mammalian model organisms, such as the fruit fly, Drosophila, and the tropical zebrafish, Danio reriro, have emerged as powerful systems for the in vivo analysis of developmental and pathological processes, offering a level of subcellular resolution and genetic manipulation not possible in more traditional mammalian organisms. The CDBG’s research is focused on using these organisms to develop novel models of inflammatory, neurodegenerative, cardiovascular, musculo-skeletal disease and cancer. In conjunction with the MRC, the CDBG offers training and employment to talented individuals who want to pursue a career in the developmental and biomedical sciences. There are more than 100 post- doctoral researchers, PhD students and technical staff currently employed. Core funding for the CDBG is provided by the Medical Research Council (MRC) while individual research projects are supported by a number of agencies including the BBSRC, British Heart Foundation, Cancer Research UK, Parkinson’s UK, The Wellcome Trust and the European Union.

Tropical zebrafish in the MRC Centre for Developmental and Biomedical Genetics


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