BIOTECHNOLOGY
NASH liver tissue showcasing the fibrotic phenotype (yellow colour) associated with the disease
Next generation DRUG DISCOVERY
Organ-on-a-chip technology helps bridge the gap between animal and human models in drug development By Audrey Dubourg product manager for CN Bio
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adly, 90% of drugs entering clinical trials ultimately fail, with insufficient efficacy remaining a leading cause for
these failures despite years of R&D and millions of pounds invested. This harsh reality points to the fact that the preclinical tests used to discover and develop drugs do not accurately reflect human outcomes.
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Unfortunately, all industry-standard models have flaws; traditional in- vitro assays are too simplistic and in-vivo animal models are too ‘animal’. The problem is now exacerbated as new advanced drug modalities, with human-specific modes of action becoming more prevalent in drug pipelines. So, what can be done to
overcome these limitations and bring much needed therapeutics to market in fast and cost effective ways - especially for diseases that are becoming more widespread? The answer: Make use of a an innovative new solution called the ‘organ-on-a- chip’ (OOC).
CN Bio’s in-a-box- solution helps recreate industry-proven models
NEW APPROACH METHODOLOGIES The complementary or alternative use of New Approach Methodologies (NAMs), such as organ-on-a-chip (OOC), offer a path forward in situations where model translatability to humans is predicted to be poor, or for testing advanced drug modalities where human-specific targets and pathways are required. The aim of OOC is to accurately replicate human physiology and function in vitro by culturing physiologically relevant combinations of primary human cells together in a perfused environment supplied by fluidic flow. Using OOC, it is now possible to recreate healthy and diseased human organ mimics in the laboratory.
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