Intractable Fatigue in Chronic Lyme Disease: Lipid Replacement Therapy(LRT®) Effective Against Fatigue


A 2012 study in the interna- tional Journal of Functional Foods in Health and Disease finds that glycophospholipids significantly reduce intrac- table fatigue in long-term pa- tients who are positive on the western blot test for Borrelia burgdorferi infection, known as Lyme Disease.1


that are easily damaged by oxidation, resulting in loss of electron transport function. In other studies, Lipid Re- placement Therapy (LRT®) was shown to improve mito- chondrial function.2, 3


The western


blot is the gold standard test for this infection, which is the most common vector-borne ill- ness in North America.


This study of 16 Lyme patients (six males and ten females) was conducted by Garth L. Nicolson, PhD, Rita Ellithorpe, MD, and Robert Setterini, MS. Patients had all been ill for an average of over 12 years, had a multi- symptom chronic condition characterized by unrelenting fatigue, joint and muscle pain, muscle aches, and memory im- pairment. An oral supplement containing a mixture of gly- cophospholipids with NADH and CoQ10 was prescribed, in doses of five capsules in the morning and five capsules in the evening. The membrane phospholipids of the mixture are essential components of the mitochondrial inner membrane


Intractable fatigue was moni- tored at 0, 7, 30 and 60 days using a validated instrument, the Piper Fatigue Scale. By the end of eight weeks, there was an overall 26% reduction in fatigue. Patients also expe- rienced significant improve- ment in well being, mood, and the ability to complete tasks.


The results in this study fol- lowed closely another recent study in the June 2012 issue of the International Journal of Clinical Medicine using the same supplement mixture on 58 patients with Chronic Fa- tigue Syndrome, Fibromyalgia Syndrome, Gulf War Illness and 17 additional patients with Chronic Lyme Disease.4


These


patients had been symptom- atic for an average of over 17 years with intractable fatigue, had seen an average of over 15 physicians and had taken an average of over 35 drugs and


supplements without resolu- tion of their fatigue. After 60 days on the glycophosphlipid supplement, the participants in the study showed an over- all 31% reduction in fatigue that was statistically highly significant. There were no ad- verse events found in these two clinical trials.


References:


1. Nicolson GL, Settineri R, Ellithorpe R. Glycophospholipid formulation with NADH and CoQ10 significantly reduces intractable fatigue in chronic Lyme disease patients: preliminary report. Funct. Food Health Dis. 2012; 2(3): 35-47.


2. Seidman M. Polyunsaturated Phos- phatidylcholine in NT Factor Im- proves Mitochondrial Function, Audi- tory Sensitivity and may Slow some of the Aging Process: Anti-Aging Medi- cal News. Winter 2001.


3. Agadjanyan M, Vasilevko V, et. al. Nutritional Supplement (NT Factor) restores mitochondrial function and reduces moderately severe fatigue in aged subjects. JCFS 11(3); 23-36 2003.


4. Nicolson GL, Settineri R, Ellithorpe R. Lipid Replacement Therapy with a gly- cophospholipid formulation with NADH and CoQ10 significantly reduces fatigue in intractable chronic fatiguing illnesses and chronic Lyme disease. Int. J. Clin. Med. 2012; 3(3): 163-170.


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