ADVERTORIAL


Robert Mattes Applications Scientist, FOSS NIRSystems, Inc.


FOSS NIRSystems on PAT


The FDA Process Analytical Technology (PAT) initiative encourages manufacturers to monitor processes before the final product stage. Near-Infrared (NIR) Spectroscopy is particularly well suited to in-line, real-time analysis, because it can be utilised with no sample preparation, used with multiplexed fibre optic probes and is robust in industrial environments.


FOSS NIRSystem has been in the NIR market for over 45 years and we have an impressive installed base of laboratory and process NIR analyzers. Our analyzers are involved in the complete process,


quality of the cores and/or the finished product. Process NIR instruments are designed to be used in-line to measure several parameters, such as residual granulating liquid in fluid bed dryers or


FOSS XDS Process AnalyticsTM Single point or multiplexed – up to 9 sampling points per instrument


The XDS MasterLabTM Automated transmission or reflectance analysis of a tray of multiple tablets, capsules, or vials


from incoming raw materials to finished products. We offer proven digital dispersive NIR analyzers, which are fast, accurate, and not sensitive to vibration. The FOSS XDS MasterLabTM


has demon -


strated to be robust and accurate in harsh manufacturing environments and includes a transmission solution designed specifically for solid dosage form analysis. It has been adopted by major pharmaceutical manufacturers to measure content uniformity of active ingredients in capsules and tablets at-line. The XDS MasterLab can be placed next to the tablet press to ensure the


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European Pharmaceutical Review Volume 16 | Issue 3 | 2011


single pot granulators. Mean particle size and polymorph conversion can also be monitored at the same time. From a quality perspective there will be a


greater need for NIR measurements throughout the process stream for quality attributes like blend uniformity and content uniformity. This is the effect of pharmaceutical manufacturers trying to reduce the number of time consuming and labor intensive measurements, like HPLC. In a global economy, qualitative analysis of raw materials at incoming inspection is becoming increasingly more important with the advent of identification


of every container and the need for the detection of counterfeit and contaminated products. The high precision of the digital dispersive FOSS NIR analyzers will play a central part in the success of these important developments. Please contact us to discuss your


specific application.


You can contact Robert Mattes directly at email: rmattes@foss-nirsystems.com FOSS NIRSystems, Inc.


7703 Montpelier Road, Laurel, MD 20723, USA Phone: +1-301-680-9600, Fax: +1-301-236-0134, Email: info@foss-nirsystems.com www.foss-nirsystems.com


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