IMPORTANT FACTS


ABOUT PREMARIN PREMARIN®


(conjugated estrogens tablets, USP) is a prescription


medicine that contains a mixture of estrogen hormones. PREMARIN is used after menopause for women to:


• Reduce moderate to severe hot flashes. • Treat menopausal changes in and around the vagina.


If you use PREMARIN only for the treatment of menopausal changes in and around the vagina, talk to your healthcare provider about whether a topical vaginal product may be better for you.


• Help reduce your chances of getting osteoporosis (thin, weak bones).


If you use PREMARIN only to prevent osteoporosis due to menopause, talk to your healthcare provider about whether a different treatment or medicine without estrogens might be better for you.


PREMARIN should be taken at the lowest dose for the shortest time possible and only for as long as treatment is needed.


IMPORTANT SAFETY INFORMATION


What is the most important information I should know about PREMARIN (an estrogen mixture)?


• Using estrogen-alone increases your chance of getting cancer of the uterus (womb). Report any unusual vaginal bleeding right away while you are taking PREMARIN because it may be a sign of cancer of the uterus.


• Do not use estrogen-alone or estrogens with progestin to prevent heart disease, heart attacks, strokes, or dementia (decline in brain function).


• Using estrogen-alone may increase your chances of getting strokes or blood clots.


• Using estrogen with progestins may increase your chances of getting heart attacks, strokes, breast cancer, or blood clots.


• Using estrogen-alone or combined with progestin may increase your chance of getting dementia, based on a study of women aged 65 years or older.


• You and your healthcare provider should talk regularly about whether you still need treatment with PREMARIN.


DO NOT TAKE PREMARIN IF YOU: • Have unusual vaginal bleeding.


• Currently have or have had certain cancers. Estrogens may increase the chance of getting certain types of cancers, including cancer of the breast or uterus. If you have or have had cancer, talk to your healthcare provider about whether you should use PREMARIN.


• Have had a stroke or heart attack. • Currently have or have had blood clots. • Currently have or have had liver problems. • Have been diagnosed with a bleeding disorder. • Are allergic to PREMARIN or any of its ingredients. • Think you may be pregnant or if you are breastfeeding.


Tell your healthcare provider: • If you have any unusual vaginal bleeding.


• About all your medical problems. Your healthcare provider may need to check you more carefully if you have certain conditions such as asthma (wheezing), epilepsy (seizures), diabetes, migraine, endometriosis, lupus, or problems with your heart, liver, thyroid, kidneys, or if you have high calcium levels in your blood.


• About all the medicines, vitamins, and supplements you take.


• If you are going to have surgery or will be on bed rest; you may need to stop taking PREMARIN.


This brief summary is based on PREMARIN tablets Patient Information LAB-0515-3.0, Rev 02/2012 ©2014 Pfizer Inc. All rights reserved. April 2014


Rx Only PRM646304-03 © PARADE Publications 2014. All rights reserved


• Heart attack • Stroke • Blood clots • Dementia • Breast cancer • Cancer of the lining of the uterus • Ovarian cancer


• New breast lumps • Unusual vaginal bleeding • Changes in speech or vision • Sudden, new severe headaches


• Headache • Breast pain


• Irregular vaginal bleeding or spotting


• Nausea and vomiting


(prem-uh-rin)


POSSIBLE SIDE EFFECTS OF PREMARIN Serious but less common side effects include:


• High blood pressure • High blood sugar • Gallbladder disease • Liver problems


• Enlargement of benign tumors of the uterus (fibroids)


• Severe allergic reaction


Call your healthcare provider right away if you get any of the following warning signs or any other unusual symptoms that concern you:


• Severe pains in your chest or legs, with or without shortness of breath, weakness, and fatigue


• Swollen lips, tongue, or face Less serious but common side effects include:


• Stomach or abdominal cramps, bloating


• Hair loss • Fluid retention • Vaginal yeast infection


These are not all the possible side effects of PREMARIN. For more information, ask your healthcare provider or pharmacist. You may report side effects to Pfizer Inc at 1-800-438-1985 or to the FDA at 1-800-FDA-1088.


What can I do to lower my chances of a serious side effect with PREMARIN?


• Talk to your healthcare provider regularly about whether you should continue taking PREMARIN.


• If you have a uterus, talk to your healthcare provider about whether the addition of a progestin is right for you to reduce the chance of getting cancer of the uterus.


• See your healthcare provider right away if you experience vaginal bleeding while taking PREMARIN.


• Have a pelvic exam, breast exam, and mammogram (breast X-ray) every year unless your healthcare provider advises you otherwise. If members of your family have had breast cancer or if you have ever had breast lumps or an abnormal mammogram, you may need to have breast exams more often.


• Ask your healthcare provider for ways to lower your chances of getting heart disease.


NEED MORE INFORMATION?


• This information does not replace talking to your healthcare provider about your menopausal symptoms and their treatment.


• Go to www.Premarin.com • Call 1-888-240-8471.


INVITE EVERYONE. A


town that facilitates every- one’s participation—from energetic young adults to retirees looking to down- size—is more likely to thrive. Immigrants can be a key part of the mix, too. According to Michael Burayidi, a professor of urban planning at Ball State University in Indiana, immigrants tend to be “enterprising” business owners whose brick-and- mortar establishments at- tract customers downtown. Burayidi points to Middle- town, Conn. (pop. 47,333), where immigrant entrepre- neurs have proven resilient even during hard times. “We appreciate every opportunity that America offers,” says Chu Ngo, a Vietnamese-born former research scientist who last year opened a restaurant called Lan Chi’s. “Here the door is open to us— and we’re going to make it work.”


12 | AUGUST 17, 2014


oped zero-interest small- business loans, in part using grants from a local foundation. And it created a program that allows new business owners to meet with several government agencies at once. “Instead of an entrepreneur getting frustrated as they’re bounc- ing between [building and fire] code departments and engineering and health, we have all those individuals meet together,” says execu- tive director Casey Woods.


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