news T
he Food and Drug Administration (FDA) has expanded the approved use of Botox
(onabotulinumtoxin A) to treat adults with overactive bladder who cannot use or do not adequately respond to a class of medications known as anticholinergics. Overactive bladder is a condition in which the bladder squeezes too often or squeezes without warning. Symptoms include leaking urine (urinary incontinence), feeling the sudden and urgent need to urinate, and frequent urination.
When Botox is injected into the bladder muscle, it causes the bladder to relax, increasing the bladder’s storage capacity and reducing episodes of urinary incontinence. Injecting the bladder with Botox is performed using cystoscopy, a procedure that allows a doctor to visualise the interior of the bladder while Botox is being injected.
The International Society of Aesthetic Plastic Surgery (ISAPS) has released the results of the third annual statistical analysis, Global Study of Aesthetic/Cosmetic Surgery Procedures Performed in 2011.
The 2012 study invited
approximately 20 000 plastic surgeons to participate. In addition, the American Society for Aesthetic Plastic Surgery (ASAPS) and the Brazilian Society of Plastic Surgery
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A round-up of news stories in the aesthetic and anti-ageing medicine industry
BOTOX TO TREAT OVERACTIVE BLADDER FDA APPROVES BOTOX FOR OVERACTIVE BLADDER FOLLOWING CLINICAL TRIALS
Clinical trial results Botox’s safety and effectiveness for this new indication were established in two clinical trials of 1105 patients with symptoms of overactive bladder. Patients were randomly assigned to receive injections of 100 units of Botox (20 injections of 5 units each) or placebo. Results after 12 weeks showed that
patients treated with Botox experienced urinary incontinence an average of 1.6–1.9 times less per day than patients treated with placebo. Botox-treated patients also needed to urinate on average 1–1.7 times
'Clinical studies have demonstrated Botox’s
ability to significantly reduce the frequency of urinary incontinence,' said Hylton V. Joffe, MD, director of the Division of Reproductive and Urologic Products in FDA’s Center for Drug Evaluation and Research. 'Today’s approval provides an important additional treatment option for patients with overactive bladder, a condition that affects an estimated 33 million men and women in the United States.'
less per day and expelled an average of 30 mm more urine than those treated with placebo. Treatment with Botox can be repeated when the benefits from the previous treatment have decreased, but there should be at least 12 weeks between treatments. Common side-effects reported during clinical trials included urinary tract infections, painful urination, and urinary retention. Botox is manufactured by Allergan Inc. based
in Irvine, CA.
STATISTICAL ANALYSIS OF PLASTIC SURGERY PROCEDURES
(SBCP) assisted. Results are projected to reflect international statistics and are exclusively based on the estimated number of plastic surgeons in each country and the respondent sample. Results reveal a hierarchy of
countries with the most surgical and non-surgical aesthetic/cosmetic procedures performed by board certified (or equivalent) plastic surgeons in 2011. Summaries provided on the ISAPS website include tables showing the number of
surgeons and procedures by country. Procedural frequency shows
modest variation lipoplasty remains the most performed procedure, representing 19.9% of total surgical procedures, while botulinum toxin type A leads with 38.1% among non-surgical procedures. The popularity of surgical procedures varied by country. The US, Brazil, China, Japan, and Italy ranked as the top five most dominant countries for surgical procedures. The survey was compiled,
tabulated, and analysed by Industry
Insights, Inc., an independent research firm based in Ohio. Final figures have been projected
to reflect international statistics and are based exclusively on the estimated number of plastic surgeons in each country. To aid in tallying the total number of plastic surgeons, representatives of national societies provided the counts for over 90% of the 32000 total estimated plastic surgeons. A formula was used to estimate numbers in non-reporting countries based on their gross domestic product and population.
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