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Monolithic Chromatography and its Modern Applications


Chapter 15 Applications of Monolithic Chromatography in Support of Pharmaceutical Development of Drug Substances and Formulations


Naijun Wuand Zhong Li 15.1 Introduction


15.2 Chromatographic Performance of Silica-based Monolithic Columns


15.3 Applications to Support Process Development of Drug Substances


15.4 Applications in Support of Formulation Development 441 15.5 Conclusions Acknowledgements References


Chapter 16 Use of Monolithic Material as On-line Extraction Support for High-throughput Liquid Chromatography Tandem Mass Spectrometry Analysis of Biological Samples


Raymond Naxing Xu, Grace E. Kim, Maria P. Metchkarova, Phillip Vaca, Matthew J. Rieser and Tawakol A. El-Shourbagy 16.1 Introduction 16.2 System Setup


16.3 ComparisonWith Liquid–Liquid Extraction 16.4 A Generic Approach for Drug Development


16.5 Highly Sensitive Determination of Pharmaceutical Compounds in Human Plasma


16.6 Applications in Urine Sample Analysis 16.7 Summary


16.8 Future Perspectives References


Chapter 17 Convective Interaction Media Monoliths for Separation and Purification of pDNA and Viruses


17.2 Structure and Characteristics of Convective Interaction Media Monoliths


17.3 Virus Applications


17.4 Plasmid DNA Purification 17.5 Summary


427 427 429 434 446


447 447


451


451 453 455 467


471 477 486 487 487


Matjazˇ Peterka, Petra Kramberger and Alesˇ Sˇtrancar 17.1 Introduction


489 489 491


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