Technology and product reviews Product


Epicel® Genzyme Biosurgery, Cambridge, MA, USA


EpiDex™ Euroderm GmbH, Leipzig, Germany


Content and description


Cultured epidermal autograft Indications/uses


Severe deep dermal, full- thickness burns


Disadvantages


2-3 week lag period between biopsy and obtaining epidermis Lacks dermal component


Cultured epidermal autograft


Treatment of chronic leg ulcers 2-3 week lag period between biopsy and obtaining epidermis Lacks dermal component Not suitable for deep burns or infected wounds


Myskin™ Altrika Ltd, Sheffield, UK


Cultured epidermal autograft


Treatment of burns, ulcers and other non-healing wounds


2-3 week lag period between biopsy and obtaining epidermis Lacks dermal component Not suitable for deep burns or infected wounds


ReCell® Avita Medical, Cambridge, UK


CellSpray® Avita Medical, Cambridge, UK


BioSeed®-S BioTissue Technologies AG, Freiburg, Germany


Lyphoderm™ Altrika, Sheffield, UK


References


33. Supp DM, Boyce ST. Engineered skin substitutes: potential and practices. Clin Dermatol 2005; 23(4): 403–12.


34. Lee W, Debasitis JC, Lee VK, et al. Multi-layered culture of human skin fibroblasts and keratinocytes through three-dimensional freeform


fabrication. Biomaterials 2009; 30: 1587–95.


35. Suzuki T, Ui K, Shioya N, Ihara S. Mixed cultures comprising syngeneic and allogeneic mouse keratinocytes as a graftable skin substitute. Transplant 1995; 59 1236–41.


SUPRATHEL™ PolyMedics Innovations GmbH, Heerweg, Germany


Absorbable, microporous membrane and alloplastic skin


Autologous cell therapy device Large surface areas of skin trauma, such as burns, scalds, traumatic wounds, scars, hypopigmentation and vitiligo


Cultured epithelial autograft suspension


Can be used alone to treat superficial burns or in conjunction with a dermal product to treat deep dermal burns


Autologous keratinocyte- fibrin glue suspension


Not suitable for infected or necrotic wounds


2-3 week lag period between biopsy and obtaining epidermis Lacks dermal component


Treatment of chronic leg ulcers 2-3 week lag period between biopsy and obtaining cells Lacks dermal component Not suitable for deep burns or infected wounds


Lysate of cultured human keratinocytes


Treatment of chronic leg ulcers 2-3 week lag period between biopsy and obtaining epidermis Lacks dermal component Not suitable for deep burns or infected wounds


Treatment of deep dermal burns, abrasions and split-skin donor sites


2-3 week lag period between biopsy and obtaining epidermis Lacks dermal component Not suitable for deep burns or infected wounds


AlloDerm® Regenerative Tissue Matrix LifeCell, Branchburg, NJ, USA


EZ-DERM™ Brennen Medical Inc, Saint Paul MN, USA


Processed human cadaver skin with acellular dermal matrix and intact basement membrane


Porcine derived xenograft in which the collagen has been chemically crosslinked with an aldehyde


31 Wounds International Vol 1 | Issue 4 | ©Wounds International 2010


Hernia repair, abdominal wall reconstruction, breast reconstruction, ENT/head and neck plastic reconstruction, grafts


Partial-thickness wounds, donor sites, sandwich autografts and full-thickness wounds before skin grafting


May necessitate removal after 2-3 weeks Autograft is needed for epithelial cover Not suitable for infected wounds


Not suitable for deep burns Not suitable for infected wounds


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