Historical aspects and milestones in HCL 5
Figure 1. Milestones in the development of effective treatment of HCL.
that molecular remissions are not attained in the vast
6. Robbins BA, Ellison DJ, Spinosa JC, et al. Diagnostic
majority of patients. Preliminary studies indicate that
application of two-color flow cytometry in 161 cases of hairy
cell leukemia. Blood 1993;82:1277–1287.
new immunotoxins are highly effective in patients
7. de Boer CJ, Kluin-Nelemans JC, Dreef E, et al. Involvement
with relapsed and refractory disease. Only one large
of the CCND1 gene in hairy cell leukemia. Ann Oncol 1996;7:
prospective randomized trial has been carried out 251–256.
within the cooperative group system in the USA
8. Vincent AM, Burthem J, Brew R, et al. Endothelial interac-
comparing 2-DCF to interferon [47,70]. The time is
tions of hairy cells: the importance of a4b1 in the unusual
tissue distribution of the disorder. Blood 1996;88:3945–3952.
right for further studies evaluating the ability to
9. Cordingley FT, Bianchi A, Hoffbrand AV, et al. Tumour
eradicate MRD after purine analogues with a variety
necrosis factor as an autocrine tumour growth factor for
of agents including Rituximab, Campath-1H or chronic B-cell malignancies. Lancet 1988;1:969–971.
BL22. The latter antibodies should indeed be tested
10. Carlos TM, Schwartz BR, Kovach NL, et al. Vascular cell
now in newly diagnosed patients and perhaps a new
adhesion molecule-1 mediates lymphocyte adherence to
cytokine-activated cultured human endothelial cells. Blood
milestone will be achieved.
1990;76:965–970.
11. Burthem J, Cawley JC. The bone marrow fibrosis of hairy-cell
Declaration of interest: The authors report no
leukemia is caused by the synthesis and assembly of a
fibronectin matrix by the hairy cells. Blood 1994;83:497–
conflicts of interest. The authors alone are respon-
504.
sible for the content and writing of the paper.
12. Ewald O. Die Leukamische Reticuloendotheleose. Deutsches
Arch Klin Med 1923;142:2222–2228.
13. Gosselin GR, Hanlon DG, Pease GL. Leukaemic reticuloen-
References
dotheliosis. Can Med Assoc J 1956;74:886–891.
14. Schrek R, Donnelly WJ. ‘‘Hairy’’ cells in blood in lymphor-
1. Bouroncle BA, Wiseman BK, Doan CA. Leukemic reticu- eticular neoplastic disease and ‘‘flagellated’’ cells of normal
loendotheliosis. Blood 1958;13:609–630. lymph nodes. Blood 1966;27:199–211.
2. Golomb Hairy cell leukemia: a clinical review based on 71 15. Hakimian D, Tallman MS, Hogan DK, et al. Prospective
cases. Ann Intern Med 1978;89:677–683. evaluation of internal adenopathy in a cohort of 43 patients
3. Golomb HM, Vardiman JW. Response to splenectomy in 65 with hairy cell leukemia. J Clin Oncol 1994;12:268–272.
patients with hairy cell leukemia: an evaluation of spleen 16. Cawley JC, Burns GF, Hayhoe FG. A chronic lymphoproli-
weight and bone marrow involvement. Blood 1983;61: ferative disorder with distinctive features: a distinct variant of
349–352. hairy-cell leukaemia. Leuk Res 1980;4:547–559.
4. Tallman MS, Peterson LC, Hakimian D, et al. Treatment of 17. Catovsky D, O’Brien M, Melo JV, et al. Hairy cell
hairy-cell leukemia: current views. Semin Hematol 1999;36: leukemia (HCL) variant: an intermediate disease between
155–163. HCL and B prolymphocytic leukemia. Semin Oncol 1984;11:
5. Bartl R, Frisch B, Hill W, et al. Bone marrow histology in 362–369.
hairy cell leukemia. Identification of subtypes and their 18. Catovsky D, Pettit JE, Galton DA, et al. Leukaemic
prognostic significance. Am J Clin Pathol 1983;79:531– reticuloendotheliosis (‘Hairy’ cell leukaemia): a distinct clin-
545. ico-pathological entity. Br J Haematol 1974;26:9–27.
Page 1  |  Page 2  |  Page 3  |  Page 4  |  Page 5  |  Page 6  |  Page 7  |  Page 8  |  Page 9  |  Page 10  |  Page 11  |  Page 12  |  Page 13  |  Page 14  |  Page 15  |  Page 16  |  Page 17  |  Page 18  |  Page 19  |  Page 20  |  Page 21  |  Page 22  |  Page 23  |  Page 24  |  Page 25  |  Page 26  |  Page 27  |  Page 28  |  Page 29  |  Page 30  |  Page 31  |  Page 32  |  Page 33  |  Page 34  |  Page 35  |  Page 36  |  Page 37  |  Page 38  |  Page 39  |  Page 40  |  Page 41  |  Page 42  |  Page 43  |  Page 44  |  Page 45  |  Page 46