PHOTONICS WEST OPTICAL DIAGNOSTICS
‘We desperately need to develop new diagnostic methods that might replace PCR to deal with future pandemics’
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‘We’ve been trying to treat [Covid-19] as a black box. The trials try drug a, drug b, drug c and then just hope for results. If we could characterise the disease in vivo in humans, there will be jumps that occur. That is the same for all diseases, but we have really learnt now with pulmonary medicine, lung injury, infection inflammation, it is a black box,’ he said. Dhaliwal referred to acute respiratory
distress syndrome (ARDS) that has been studied for the last 20 years, with minimal advances in understanding and treating the disease. ‘Trials have failed for ARDS. A lot of drug companies were not interested in acute infection acute pathogenicity. Photonics can make a huge difference to changing that paradigm. We need to take photonics into the person,’ he said. As vaccinations are rolled out, Nielson said antibody testing will become more important, needing to be simple, low-cost and reliable. ‘Photonics could help with this development of rapid diagnostics for the assessment of antibodies,’ she said. This will also be crucial in low-resource
areas, where vaccines will be in limited supply, added Dr Neema Kaseje, of Doctors Without Borders, who has helped develop Covid-19 health strategies in Kenya. ‘In Kenya we have received one million doses of the vaccine and the population is 55 million. We will never receive 55 million
More advanced endoscopes are key for understanding better how diseases affect the lungs
doses, but if there is antibody testing, we could manage our resources more effectively, saving the vaccines for those with no antibodies,’ she said.
It comes down to trust For new technologies to be translated into clinics successfully, funding for diagnostics needs to be rethought, Garner reiterated, which is key for end-users to gain trust in new technologies. ‘There is funding to make that test, to
do the first 100 patients, but there is no funding to do a large-scale POC clinical trial,’ he said. ‘Until that issue is addressed, it’s very hard for clinicians to then look at what you have with new technology,
and trust that result. I run a gold-standard diagnostic laboratory and it is sometimes hard to trust the results coming out there. Because they just do not match what is going on diagnostically,’ Garner continued. ‘If you have a test that goes wrong once,
you’re already starting to lose the trust of the clinician, if you have a test that goes wrong 50 per cent of the time, that test is actually unusable. ‘If the funding is there to really study the
real-world application of these diagnostics, and to study it quickly – in a setting where you have a robust dataset – that is how we build trust,’ he said. ‘But it takes a change from the organisations that are providing that funding.’ EO
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