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Case study: Managing biological samples STARLIMS biorepository solutions boost efficiency, cost effectiveness, and increase sample management by 25 per cent
Our client is a global, research-driven biopharmaceutical
organisation that develops treatments for major diseases. Their diverse research stage biologics R&D encompasses protein, peptide and antibody candidates, and in house and collaborative projects (e.g., biologic drugs, biological products). STARLIMS was chosen in
2012 to replace the firm’s legacy CambridgeSoft and Freezerworks inventory platforms for its biologics samples that are used for biological manufacturing. The legacy system was not centralised, there was no capability for tracking biological samples, and sample management was primarily dependent upon staff at individual repository sites filling out spreadsheets. During late 2012, the firm installed STARLIMS as an infrastructure for its Global Biologics Inventory System (GBIS). By 2017, the STARLIMS GBIS managed approximately 200,000 peptides, protein and antibody samples and cell lines within their global inventory. Since deploying STARLIMS, the number of requests actioned by repository staff has increased from just 10s per day to 100s per day. STARLIMS was first deployed at a single cell bank in 2012, where it was used to process some 4,000 requests over a two-year period. After another 12 months of development, customisation, enhancements and beta testing at individual sample storage labs, the STARLIMS GBIS platform was deployed across multiple sample storage sites. Alpha Engineering acted as lead developer for
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the complete STARLIMS GBIS project. STARLIMS now manages the
complete GBIS, including the firm’s biologics pharmacy, which the firm estimates processed more than 10,000 requests over the 2015-2017 period. STARLIMS operates as a
central database to manage and track the location and quantity of each sample in the biologics inventory, at every repository site. The firm’s research and biologics drug development teams around the world can now
‘The STARLIMS inventory platform was rolled out the week after Thanksgiving. We anticipated spending January and February fixing initial issues, but there were none. It just worked’
request samples for delivery to their biological manufacturing laboratories quickly and cost- effectively.
Installation of the STARLIMS
GBIS framework has significantly boosted the efficiency and cost-effectiveness of early drug development and increased sample security. • There is no unnecessary and costly duplication of biological manufacturing because the quantity and location of existing stock can be confirmed instantly.
• Staff can ship samples in bulk from different sites to local repositories to simplify logistics, cut both transport
and potentially customs costs, and expedite delivery so that studies aren’t delayed.
• All movement of samples is tracked and logged, so samples can never be misplaced or lost.
By replacing the legacy system with STARLIMS, the firm was able to develop a more productive pharmacy for biologics and biopharmaceuticals, with leveraged distributed storage, and an easy to use request system that is transparent to end user distribution. There was no ability to
integrate and interface with disparate inventory systems across the organisation. This meant that it was very difficult to determine an accurate count of the available inventory of biologic samples, and/or biological products, and repositories. STARLIMS allows for
seamless integration into different applications within the organisation’s biosphere. STARLIMS can be easily configured, which allows for the implementation of specific workflows with complex business rules. The need to minimise
overheads STARLIMS offers a single application The organisation transformed its biologics associated with inventory operations, for all inventory applications. The sample inventory from a system of poorly while maximising
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the benefits of global ability to locate and redirect samples documented spreadsheets and other home visibility and intelligent centralisation. easily increases productivity, reduces unnecessary sample manufacture, simplifies transport logistics and dramatically reduces costs. grown systems to a centrally maintained, IT- managed infrastructure. The STARLIMS GBIS is flexible
to meet the needs of scientists, while ensuring sample security, and simplifying and speeding the request process and sample delivery. The organisation has
separately interfaced the STARLIMS inventory with its biologics registration system. When a protein or other biological sample is created and registered into the system, the registration data can be imported straight into the inventory, all sample-related metadata keyed into registration is imported automatically into the inventory, which saves work, repetition and ensures there are no transcription errors. Building on the success of STARLIMS for its Global Biologics Inventory System, the organisation is also constructing a STARLIMS infrastructure to manage its 200,000 to 300,000 clinical trial sample biorepository.
Summer 2020 Scientific Computing World 19
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