CONTENTS & COMMENT & CONTENTS
Front cover The publishers would like to thank Contec for the use of their images on the front cover of Cleanrooms & Contamination Control 2017
2 & 3 Using BIM In The source guide for engineers, scientists and technicians
The disposable cleanroom!
If you can’t conveniently get to the cleanroom, then why not bring the cleanroom to the project?
cleanroom construction Building Information Modelling has been used in a modular cleanroom construction project to make best use of constrained available space.
5 & 6 Overcoming the
germ burden Cherwell Laboratories has issued a guide on decontamination of pharmaceutical cleanrooms to keep them both particle and germ free.
9 Lifting without
shedding Altman provides a range of lifting equipment to suit cleanroom environments to perform heavy duties without shedding particles in sensitive areas.
12 New cleanroom for
pharma specialist Pharmaceutical supplier installs 5000 square metre cleanroom facility to produce drug products in line with FDA good manufacturing practice guidelines.
15, 16 & 19 Company Guide A guide to cleanroom and contamination control related suppliers.
20 Clean laboratory produces tiny laser
hile many researchers are fortunate to be able to use on-site cleanroom facilities, what if these are unavailable? Many scientists and engineers are faced with the problem of either going to the great expense of building a cleanroom, which may be impractical for start-up companies, or the inconvenience of
travelling long distances to rent, beg, borrow or steal facilities from others. An example of a researcher using external cleanroom facilities to develop a miniature laser is described on page 20. But a more common scenario is that of Dr Gianmario Scotti from the
array Finnish researchers have been using clean nanofabrication facilities to produce an operating dark lattice plasmonic nanolaser.
University of Helsinki, Finland. He was fed up working in the cleanroom about 15 km away from his lab. The microchips intended for mass spectrometry analysis had to be prepared in bigger batches, as there was no point spending time suiting up and using the cleanroom for just a single device at a time. That of course meant waiting for the batch to be ready before it could be used by the research group, and the work was not proceeding as fast as he would wish. Then Scotti and a colleague had an idea. Maybe they could skip the cleanroom phase by devising a small, disposable container which could be directly connected to a mass spectrometer and used to study reactions? With the help of some lateral thinking, a few grammes of plastic filament and a 3D printer, they made an unique device for studying chemical reactions, and improved their experimental processes. 3D printers are not hard to find, and printing one microreactor at a time takes about an hour. Finding the right material, however, was not an easy task. The material had to be such that the solvents used in chemical reaction studies would not dissolve anything from it. It also had to be durable and easily printable. Polypropylene filament seemed an interesting option. After a handful of developmental phases the researchers created a microreactor that can be used for mass spectrometry analysis. An additional challenge was to find a suitable platform on top of which the microreactor could be printed. The printed plastic needs to stick to the platform, but not too strongly. The researchers found that polypropylene itself is also the best platform material, but the temperature of the printed plastic must be carefully regulated. The term “microreactor” sounds complicated, but basically it is just a small container with a stir bar for mixing chemical samples and a very thin needle for spraying and ionising the sample for analysis with a mass spectrometer. The microreactor itself sits in a plastic jig to which the sample syringes are connected. The jig itself is – of course – also 3D printed. A miniature cleanroom for work on a molecular scale!
Andy Pye, Editor © Concorde Publishing Ltd 2017 Join us online at https://goo.gl/inAElE
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