PROCESS AIDS AND LUBRICANTS | PROCESSING
ments related to the strict regulations and change- management requirements in medical markets.
Low-retention additives In labware, medical devices and biopharmaceutical manufacturing equipment, such as tubing and connectors, surface-modification additives enhance the ability of fluids to flow through and not be retained on the surface of a plastic component. Techmer PM’s patent-pending, non-fluorinated
Techsurf Low Retention surface modification additive technology can provide an enhanced hydrophobic surface to improve fluid flow. Applications include biopharmaceutical processing equipment, such as single-use bioreactor vessels, connectors, and tubing, as well as drug delivery devices, microfluidic channels in diagnostic chips or cartridges, point-of- care diagnostic devices, and labware. A hydrophobic surface has a low surface energy
that repels water, so that aqueous fluids flow more easily. Fluorinated materials have traditionally been used to create this effect, because the strong electronegativity of fluorine atoms causes the surface to repel water, said Laurence Chow, Application Development Engineer at Techmer PM.
Siloxane and its derivatives have been used to create hydrophobicity, but these additives also face regulatory restriction in the EU and present a risk of negative interaction with some biologic drug substances. Amide-based additives can also improve hydrophobicity, but these migratory additives pose some risk in biopharmaceutical applications. Techmer PM has designed its Techsurf Low
Retention additives to create a hydrophobic surface with chemistries that will provide current and upcoming regulatory compliance. The additive family includes two fluorine-free chemistries (NF1
Americhem’s EcoLube MD line of PFAS- free internally lubricated compounds has been
developed for medical devices
IMAGE: SHUTTERSTOCK
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60
