the product compared to the control group. These results encouraged Framelco to conduct more research into the glyceride product and its effect on PRRSv. At a farm suffering from a severe PRRSv outbreak in Belgium, the effects of the glyceride product were studied. Firstly, one group of sows received regular feed and served as a control group. The second group of sows received the glyceride product before farrowing and during lactation. The weaned piglets also received the product. In general, the farmer was quite satisfied with the improve- ments obtained in the group receiving the glycerides of C12 compared to the control group. More specifically, pre-weaning mortality was reduced by 29% in the treatment group. The number of weaned piglets in the treatment group increased by 2.2 piglets per sow, an increase of 19.5%. Interestingly, weaned piglets in the control group received more individual injections against locomotor problems com- pared to the treatment group (3.2% versus 1.9% of the total amount of weaned piglets). Based on historical data the caus- ative agent of these locomotor problems was most likely S. suis. Hence, glycerides of C12 seemed to have suppressed the susceptibility to secondary infections with S. suis.
Glyceride and PRRSv shedding To study the effect of the glyceride product on PRRSv shed- ding, a Poulpharm research team collected oral fluids from weaned piglets. At seven and 37 days after weaning, ten
pens were randomly selected and provided with chewing ropes. Piglets were allowed to chew the ropes for 45 min- utes, after which oral fluids were collected for analysis. The team analysed oral fluids by an RT-qPCR-test with a cut-off Ct-value of 42. Values of 42 and higher were reported as negative, whereas values below 42 reflected a positive result, with lower values indicating a higher PRRSv concentration. At seven days after weaning, 20% of the pens in the control group tested positive for PRRSv, whereas in the treatment group this was 10%. At 37 days after weaning, 70% of the pens in the control group tested positive and only 20% in the treatment group. Based on these results, it seemed that FRA C12 Dry reduced PRRSv shedding in weaned piglets. To understand the mode of action of glycerides of C12 against PRRSv better, an in vitro test is currently being exe- cuted. The aim of this trial is to investigate the possible direct antiviral effect of glycerides of lauric acids against PRRSv and its ability to modulate the production of several cytokines in PRRSv-infected cells. Although the mode of action is currently not yet fully under- stood, glycerides of lauric acid seem to be an interesting and promising tool assisting directly and/or indirectly in the viral clearance of PRRSv and in controlling the risk of secondary infections in PRRSv-positive pigs.
References are available on request. ▶ PIG PROGRESS | Volume 37, No. 4, 2021 23
Glycerides of lauric acid may be a tool for con- trolling the risk of secondary in- fections in PRRSv-positive pigs.
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